Efectos de la administración de betabloqueante en la remodelación ventricular inducida por el tabaquismo en ratas
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Data
2009-06-01
Autores
Duarte, Daniella R. [UNESP]
Oliveira, Lucienne C. [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Gaiolla, Paula Schmidt Azevedo [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Campana, Álvaro O. [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
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Resumo
Background: The role of the adrenergic system on ventricular remodeling induced by cigarette smoking is unknown. Objective: To investigate the influence of propranolol on ventricular remodeling induced by exposure to tobacco smoke. Methods: Rats were divided into three groups: 1) C, n=10 - control group; 2) F, n=10 - animals exposed to tobacco smoke; 3) BB, n=10 - animals receiving propranolol and exposed to tobacco smoke (40 mg/kg/day). After 2 months, the animals underwent echocardiographic and morphometric analyses. One-way ANOVA (mean ± standard deviation) or the Kruskal-Wallis test (median and interquartile interval) was used. Results: Group BB showed a lower heart rate than group F (C = 358 ± 74 bpm, F = 374 ± 53 bpm, BB = 297± 30; P = 0.02). Group F showed greater end-diastolic diameters (C = 18.6 ± 3.4 mm/kg, F = 22.8 ± 1.8 mm/kg, BB = 21.7 ± 1.8 mm/kg; P = 0.003) and left ventricular (LV) end-systolic diameters (C = 8.6 ± 2.1 mm/kg, F = 11.3 ± 1.3 mm/kg, BB = 9.9 ± 1.2 mm/kg; P = 0.004), adjusted for body weight (BW) and a tendency towards a lower ejection fraction (C = 0.90 ± 0.03, F = 0.87 ± 0.03, BB =0.90 ± 0.02; P = 0.07) than group C. Group BB showed a tendency towards a lower LV/BW ratio than group F (C = 1.94 (1.87 - 1.97), F = 2.03 (1.9-2.1) mg/g, BB = 1.89 (1.86-1.94); P = 0.09). Conclusion: Administration of propranolol attenuated some of the variables of ventricular remodeling induced by the exposure to tobacco smoke in rats.
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Palavras-chave
Adrenergic beta-antagonists/administration & dosage, Rats, Smoking, Ventricular remodeling, propranolol, animal experiment, animal model, body weight, cigarette smoking, controlled study, echocardiography, heart ejection fraction, heart rate, heart ventricle remodeling, male, morphometrics, nonhuman, rat, Adrenergic beta-Antagonists, Animals, Inhalation Exposure, Male, Models, Animal, Propranolol, Rats, Wistar, Tobacco Smoke Pollution, Ventricular Dysfunction, Left, Ventricular Remodeling
Como citar
Arquivos Brasileiros de Cardiologia, v. 92, n. 6, 2009.