A systematic review of anti-inflammatories for mild to moderate carpal tunnel syndrome
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Data
2009-09-01
Autores
Filho, Pedro Tadao Hamamoto [UNESP]
Leite, Fabio Vicente [UNESP]
Ruiz, Tânia [UNESP]
Resende, Luiz Antonio de Lima [UNESP]
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Resumo
The purpose of this study was to evaluate anti-inflammatory drugs in the medium- and long-term management of mild to moderate carpal tunnel syndrome (CTS). The authors conducted a systematic review of the literature on the effectiveness of steroidal and nonsteroidal anti-inflammatory drugs for mild and moderate cases of CTS. There were included only randomized, double-blind clinical trials. Six publications referring to five trials were included in the review. No study on nonsteroidal anti-inflammatory drugs met our inclusion criteria. Although neurophysiological studies have not shown great differences resulting from the application of corticosteroids, the symptomatic benefit provided by such drugs is clear. In the short term, local infiltration provides better results than systemic administration of corticosteroids. Over a 1-year period, however, this difference does not persist. Further double-blind randomized trials evaluating therapeutic efficacy for a longer follow-up period are required to provide stronger evidence for both steroidal and nonsteroidal anti-inflammatories. © 2009 by Lippincott Williams & Wilkins.
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Palavras-chave
Anti-inflammatories, Carpal tunnel syndrome, Systematic review, antiinflammatory agent, betamethasone acetate, betamethasone sodium phosphate, corticosteroid, methylprednisolone, nonsteroid antiinflammatory agent, placebo, prednisolone, steroid, antiinflammatory activity, carpal tunnel syndrome, clinical trial, comparative study, disease severity, electroneurography, electrophysiology, follow up, human, log rank test, neurophysiology, priority journal, review, systematic review, Adrenal Cortex Hormones, Anti-Infective Agents, Anti-Inflammatory Agents, Non-Steroidal, Carpal Tunnel Syndrome, Humans, Injections, Intra-Articular, Randomized Controlled Trials as Topic, Treatment Outcome
Como citar
Journal of Clinical Neuromuscular Disease, v. 11, n. 1, p. 22-30, 2009.