Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
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Data
2010-12-01
Autores
Cavallini, Daniela Cardoso Umbelino [UNESP]
Abdalla, Dulcineia S. P.
Pauly-Silveira, Nadiege D. [UNESP]
Rossi, Elizeu Antonio [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Colegio Farmaceuticos Provincia de Buenos Aires
Resumo
Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0,30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.
Descrição
Palavras-chave
Atherosclerosis, Autoantibodies against oxidized LDL, Simvastatin
Como citar
Latin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 29, n. 8, p. 1419-1424, 2010.