SFlt-1 and IP-10 in women with early-onset preeclampsia
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Data
2011-04-01
Autores
Oliveira, Leandro Gustavo de [UNESP]
Câmara, Niels Olsen S.
Peraçoli, José Carlos [UNESP]
Peraçoli, Maria Terezinha Serrão [UNESP]
Moron, Antonio F.
Sass, Nelson
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Resumo
Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5 pg/mL in preeclamptic women, as compared with 52.28 pg/mL in the controls (P = 0.0028). The mean serum level of sFlt-1 was 13,636 pg/mL in preeclamptic women, as compared with 2020 pg/mL in the controls (P < 0.0001). PlGF levels were significantly lower in women with preeclampsia. © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
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Palavras-chave
Angiogenic factors, Inflammation, IP-10, PlGF, Preeclampsia, sFlt-1, gamma interferon inducible protein 10, placental growth factor, vasculotropin receptor 1, adult, chemoluminescence, clinical article, controlled study, cytometry, female, human, hypothesis, immunoassay, inflammation, pathogenesis, preeclampsia, protein blood level
Como citar
Pregnancy Hypertension, v. 1, n. 2, p. 129-131, 2011.