Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
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Data
2011-07-01
Autores
Ramalli Jr, Edvaldo Luiz
Braga, Leonardo Henrique
Evora, Patricia Martinez [UNESP]
Albuquerque, Agnes Afrodite Sumarelli
Celotto, Andrea Carla
Mota, André Lupp
Evora, Paulo Roberto Barbosa
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Resumo
Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridges.
Descrição
Palavras-chave
Coronary circulation, Endothelium, Myocardial bridging, ACE protein, human, dipeptidyl carboxypeptidase, endothelin 1, adipose tissue, coronary artery blood flow, coronary artery disease, coronary blood vessel, histology, human, metabolism, myocardial bridging, paracrine signaling, pathology, pathophysiology, physiology, prenatal development, review, vascular endothelium, Adipose Tissue, Coronary Artery Disease, Coronary Circulation, Coronary Vessels, Endothelin-1, Endothelium, Vascular, Humans, Myocardial Bridging, Paracrine Communication, Peptidyl-Dipeptidase A
Como citar
Brazilian Journal of Cardiovascular Surgery, v. 26, n. 3, p. 440-446, 2011.