Effect of Usnic Acid on Candida orthopsilosis and C. parapsilosis
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Data
2012-01-01
Autores
Pires, Regina Helena [UNESP]
Lucarini, Rodrigo
Mendes-Giannini, Maria José Soares [UNESP]
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Amer Soc Microbiology
Resumo
The activity of usnic acid against Candida orthopsilosis and Candida parapsilosis on planktonic and biofilm conditions was investigated by using a broth microdilution and microplate methods. Potent in vitro activities against different Candida species were obtained. The metabolic activity of sessile cells of C. parapsilosis complex was reduced by 80% at four times the 80% inhibitory concentration. The in vitro studies support further efforts to determine whether usnic acid can be used clinically to cure patients with Candida infections.
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Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 56, n. 1, p. 595-597, 2012.