Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
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Data
2011-12-23
Autores
Marini, Gabriela [UNESP]
Piculo, Fernanda [UNESP]
Barbosa, Angélica Mércia Pascon [UNESP]
Damasceno, Débora Cristina [UNESP]
Matheus, Selma Maria Michelin [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
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Resumo
Aims: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. Source of Data: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. Summary of Findings: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. Conclusions: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.
Descrição
Palavras-chave
Animal, Diabetes mellitus/physiopathology, Female, Models, Muscle, Rats, Striated/anatomy histology, Urethra/anatomy histology, Urinary incontinence/physiopathology, diabetes mellitus, disease association, disease model, experimental rat, experimental study, female, human, morphology, nonhuman, pathophysiology, review, skeletal muscle, systematic review, urethra, urine incontinence
Como citar
Scientia Medica, v. 21, n. 4, p. 191-195, 2011.