Soybean glycinin (11S) increases HDL-cholesterol in hypercholesterolemic rats
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Data
2012-03-01
Autores
Fassini, Priscila Giácomo [UNESP]
de Souza Ferreira, Ederlan [UNESP]
da Silva, Maraiza Aparecida [UNESP]
Neves, Valdir Augusto [UNESP]
Demonte, Aureluce [UNESP]
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Resumo
Purpose: The purpose of this paper is to determine the effects of isolated soy glycinin (11S) on lipid metabolism in animals subjected to a hypercholesterolemic diet. Design/methodology/approach: Male Wistar rats were kept in individual cages under appropriate conditions. The animals were divided into three groups (n=9): normal diet (STD) given a diet containing casein as protein source, recommended in AIN-93M; hypercholesterolemic (HC) fed a normal diet with 1 per cent cholesterol and 0.5 per cent cholic acid; and hypercholesterolemic+glycinin (HC+11S), fed a hypercholesterolemic diet, plus 11S soy protein (300 mg/kg/day), dissolved in saline and administered by gavage. After 28 days, the animals were sacrificed and blood and liver removed for biochemical analysis of total cholesterol (TC), HDL-cholesterol (HDL-C) and triglycerides (TG) in the plasma, hepatic TC and TG. Findings: A single daily dose of glycinin given to the hypercholesterolemic group demonstrated its functional role, particularly in raising HDL-C and reducing triglycerides in the liver. Originality/value: This study demonstrates the action of the 11S globulin in soybean as a serum lipid lowering agent, in addition to its nutritional properties, especially in raising the HDL-C. © Emerald Group Publishing Limited.
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Cholesterol, Diet, Experimental model, Hypercholesterolemia, Metabolism, Soybean glycinin, Animalia, Glycine max, Rattus, Rattus norvegicus
Como citar
Nutrition and Food Science, v. 42, n. 2, p. 102-110, 2012.