TNFa-e microsatellite, HLA-DRB1 and-DQB1 alleles and haplotypes in Brazilian patients presenting recently diagnosed type 1 diabetes mellitus
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Data
2006-01-01
Autores
Rassi, Diane M.
Wastowski, Isabela J.
Simoes, Renata T.
Rodrigues, Sandra
Deghaide, Neife N. H. S.
Mendes-Junior, Celso T.
Simoes, Aguinaldo L.
Soares, Christiane Pienna [UNESP]
Passos, Geraldo A. S.
Donadi, Eduardo A.
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Editor
Blackwell Publishing
Resumo
TNF microsatellite and HLA class II polymorphisms were studied in 28 recently diagnosed Brazilian patients presenting type 1 diabetes mellitus (T1DM) and in 120 healthy controls. TNFa-e and HLA-DRB1/DQB1 alleles were identified using sets of sequence-specific primers. Compared to controls, the DRB1* 03 and DQBI*02 allele groups, TNFa1 allele, and the TNFa4-b5-c1-d4-e3 and TNFa10-b5-c1-d4-e3 haplotypes were overrepresented in patients. TNF microsatellite together with HLA polymorphisms is associated with type 1 diabetes in Brazilian patients, corroborating the participation of the MHC genes in disease susceptibility.
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Palavras-chave
type 1 diabetes mellitus, polymorphism, TNF microsatellite, HLA
Como citar
Immunology of Diabetes Iv: Progress In Our Understanding. Oxford: Blackwell Publishing, v. 1079, p. 300-304, 2006.