Physicochemical Characterization and Development of a Microemulsion System for Transdermal Use
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Data
2010-01-01
Autores
Silva, Jose A.
Bedor, Danilo C. G.
Damasceno, Bolivar P. G. L.
Oliveira, Anselmo Gomes de [UNESP]
Egito, E. Socrates T.
Santana, Davi P.
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Taylor & Francis Inc
Resumo
A microemulsion (ME) carrier system containing diclofenac diethylamine (DDA) was developed and physicochemically characterized. In addition, a methodology for analytical determination of DDA by UV-Vis spectrophotometry was validated. The methodology used to produce the ME was simple and reliable, producing a stable ME system with a high DDA entrapment efficiency of 89.6 +/- 14.19%. The ME system presents a mean droplet size, conductivity, pH, refractive index and viscosity of around 50 nm, 300 mu S cm(-1), 7.0, 1.399, and 110 mPa, respectively. Furthermore, the analytical method developed to evaluate the DDA content was validated and used to quantify DDA in the ME formulations.
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Diclofenac diethylamine, microemulsion, pseudo-ternary phase-diagram, spectrophotometry, stability, validation
Como citar
Journal of Dispersion Science and Technology. Philadelphia: Taylor & Francis Inc, v. 31, n. 1, p. 1-8, 2010.