Trends in rheumatic fever: clinical aspects and perspectives in prophylactic treatments
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Data
2012-09-01
Autores
Silva, Kattya Gyselle de Holanda E.
Barratt, Gillian
Oliveira, Anselmo Gomes de [UNESP]
Tabosa do Egito, Eryvaldo Socrates
Título da Revista
ISSN da Revista
Título de Volume
Editor
Informa Healthcare
Resumo
Introduction: Rheumatic fever (RF), a systemic illness that may occur following Group A beta-hemolytic streptococcal (GABHS) pharyngitis in children, is a major problem in countries with limited resources. Because of its long track record and low cost, an injection of benzathine penicillin G (BPG) suspension every 3 or 4 weeks has been used as secondary prophylaxis. Despite its excellent in vitro efficacy, the inability of BPG to eradicate GABHS has been frequently reported.Areas covered: This work reviews the possible causes of failure, as well as the inconvenience of the current prophylactic treatment of acute RF and suggests a new pharmacotherapeutic system that could replace the current one.Expert opinion: RF is a major problem concerning only countries with limited resources and could be considered as a neglected disease. The dose regimen using BPG suspension results in failures, which could be avoided by the use of nanocarrier-based systems. To meet this ultimate goal, the research should be transposed from the laboratory scale to an industrial and clinical application level. This research should be conducted to produce a pharmaceutical dosage form that will be commercially available, consumed by and affordable for patients. However, health, environmental and socioeconomic hazards should be considered.
Descrição
Palavras-chave
benzathine penicillin G, microemulsion, nanotechnology, rheumatic fever
Como citar
Expert Opinion on Drug Delivery. London: Informa Healthcare, v. 9, n. 9, p. 1099-1110, 2012.