Controlled transscleral drug delivery formulations to the eye: establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis
Nenhuma Miniatura disponível
Data
2010-08-01
Autores
Paganelli, Fernando
Cardillo, Jose A.
Dare, Alessandro R. J.
Melo, Luiz A. S.
Lucena, David R.
Silva, Arnobio A. [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
Pizzolitto, Antonio Carlos [UNESP]
Lavinsky, Daniel
Skaf, Mirian
Título da Revista
ISSN da Revista
Título de Volume
Editor
Informa Healthcare
Resumo
Importance of the field: The use of topical agents poses unique and challenging hurdles for drug delivery. Topical steroids effectively control ocular inflammation, but are associated with the well-recognized dilemma of patient compliance. Although administration of topical antimicrobials as prophylaxis is acceptable among ophthalmologists, this common practice has no sound evidence base Developing a new antimicrobial agent or delivery strategy with enhanced penetration by considering the anatomical and physiological constraints exerted by the barriers of the eye is not a commonly perceived strategy. Exploiting the permeability of the sclera, subconjunctival routes may offer a promising alternative for enhanced drug delivery and tissue targeting.Area covered in this review: Ocular drug delivery strategies were reviewed for ocular inflammation and infections clinically adopted for newer class of antimicrobials, which use a multipronged approach to limit risks of endophthalmitis.What the reader will gain: The analysis substantiates a new transscleral drug delivery therapeutic approach for cataract surgery.Take home message: A new anti-inflammatory and anti-infective paradigm that frees the patient from the nuisance of topical therapeutics is introduced, opening a large investigative avenue for future improved therapies.
Descrição
Palavras-chave
antibiotics, antimicrobials, cataract surgery, endophthalimitis, eye drops, eye infections, intraocular penetration, ocular drug delivery
Como citar
Expert Opinion on Drug Delivery. London: Informa Healthcare, v. 7, n. 8, p. 955-965, 2010.