Prospective study for the development of emulsion systems containing natural oil products
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Data
2012-07-01
Autores
Xavier-Junior, F. H.
Silva, K. G. H.
Farias, I. E. G.
Morais, A. R. V.
Alencar, E. N.
Araujo, I. B.
Oliveira, Anselmo Gomes de [UNESP]
Egito, E. S. T.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Editions Sante
Resumo
Copaiba oil, when used as anti-inflammatory and anti-infective agent, presents two major problems: i) low absorption and bioavailability and ii) an unpleasant taste. Once an appropriate emulsion was achieved, the samples were prepared using different surfactant binary mixtures to obtain a range of HLB values between 4.5 and 16.5. The HLB value of copaiba oil was 14.8; this system has been stable for more than one year, and the pseudo-ternary diagrams were useful to describe the component proportions. These results indicated that the copaiba oil emulsion might be a promising vehicle for topical delivery of drugs and active cosmetic ingredients.
Descrição
Palavras-chave
Emulsion, Copaiba oil, Hydrophilic-lipophilic balance, Pseudo-ternary phase diagram, Stability analysis
Como citar
Journal of Drug Delivery Science and Technology. Paris: Editions Sante, v. 22, n. 4, p. 367-372, 2012.