Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol
Carregando...
Data
2011-01-01
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
A validation study of an UV spectrophotometric method was conducted for quantitative analysis of benznidazol (BZN) in a lipid. The analytical determinations were performed at 315 nm at 25 ºC. The emulsion components did not interfere on drug analyses, demonstrating the specificity of the methodology. A good linearity (r = 0.99995) and precision (RSD < 5.0%) for intra and inter-day studies, including the reproducibility test were observed. The accuracy ranged of 102.1 + 2.8 e 103.8 + 1.7%. The statistical analysis demonstrates a linear, precise, accurate and robust method for BZN quantification from the lipid emulsion system.
Descrição
Palavras-chave
benznidazol, lipid emulsions, UV-Vis spectrophotometry
Como citar
Química Nova. Sociedade Brasileira de Química, v. 34, n. 8, p. 1459-1463, 2011.