Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin

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Data

2011-12-01

Autores

Kitagawa, Rodrigo Rezende
Vilegas, Wagner [UNESP]
Carlos, Iracilda Zeppone [UNESP]
Raddi, Maria Stella Gonçalves [UNESP]

Título da Revista

ISSN da Revista

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Editor

Sociedade Brasileira de Farmacognosia

Resumo

Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities.

Descrição

Palavras-chave

5-methoxy-3,4-dehydroxanthomegnin, cytotoxic activity, immunomodulatory, naphthoquinone

Como citar

Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 6, p. 1084-1088, 2011.