Treinamento aeróbio na prevenção da doença hepática não alcoólica decorrente da obesidade em ratos
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Data
2013-02-07
Autores
Moura, Leandro Pereira de [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
A obesidade é um problema de saúde pública mundial e está fortemente relacionada com a resistência à insulina. Esta última encontra-se associada à doença hepática gordurosa não alcoólica (DHGNA), doença caracterizada pelo acúmulo de gordura no fígado, que pode levá-lo à falência. Na atualidade, o tratamento sugerido para DHGNA consiste na diminuição da ingestão de gordura associada à atividade física. Contudo, pouco se sabe quanto aos protocolos de treinamento mais adequados para a prevenção ou tratamento dessa doença. O presente estudo visou analisar os efeitos do exercício físico na intensidade de 80% do limiar anaeróbio (LAn) sobre marcadores de DHGNA em ratos obesos. Para a indução da obesidade, os animais, a partir dos 90 dias de idade, foram mantidos com dieta hiperlipídica/hipercalórica (35% de gordura animal/vegetal) e os animais controles tratados com dieta balanceada (AIN-93M). Todos os animais foram submetidos a testes de lactato mínimo para a identificação do limiar anaeróbio (LAn) durante exercício de natação. Parte dos animais de cada grupo foi submetida ao treinamento por natação, em intensidade equivalente a 80% do LAn, 1 h/dia, 5 dias/semana, por 16 semanas. Outra parte teve o treinamento suspenso após 8 semanas, ficando em observação por 8 semanas adicionais. Outra parte, ainda, permaneceu sedentária ao longo de todo o experimento. Foi possível padronizar um protocolo de determinação da capacidade aeróbia para ratos recém-nascidos, o exercício físico realizado desde a infância até aos 90 dias de idade contribui na redução do ganho de peso, melhora no metabolismo da glicose e menor acúmulo de gordura hepática. O destreinamento fez com que algumas melhorias metabólicas decorrentes do exercício físico fossem neutralizadas, assim como o ganho de peso. Visto...
Obesity is a public health problem worldwide and is strongly associated with insulin resistance. The latter is associated with nonalcoholic fatty liver disease (NAFLD), a disease characterized by accumulation of fat in the liver that can lead you to organ failure. Currently, the suggested treatment for NAFLD is decrease in fat intake associated with increase in physical activity. However, little is known about the most appropriate training protocols for the prevention or treatment of this disease. This study aims to examine the effects of exercise at the intensity of the 80% of anaerobic threshold (AT) on markers of NAFLD in obese rats. To induce obesity, 90 days old rats, will be maintained with a high fat / higher calorie diet (35% of animal fat / vegetable fat). Control rats will be treated with a balanced diet (AIN-93M). All animals will be submitted to the lactate minimum test to identify the anaerobic threshold (AT) during swimming exercise. Part of the animals from each group will be subjected to swimming training in intensity equivalent to 80% of the individual AT, 1 h / day, 5 days / week for 16 weeks, another part of them will have exercise training suspended after 8 weeks, remaining under observation for additional 8 weeks, while others will remain sedentary throughout the experiment. It was possible to standardize a protocol to determine the aerobic capacity to newborn rats, physical exercise performed from infancy up to 90 days of age helps in reducing weight gain, improves glucose metabolism and reduced hepatic fat accumulation. The detraining made that some metabolic improvements resulting from the exercise were neutralized, as well as weight gain. Based on this, it is concluded that regular exercise can be... (Complete abstract click electronic access below)
Obesity is a public health problem worldwide and is strongly associated with insulin resistance. The latter is associated with nonalcoholic fatty liver disease (NAFLD), a disease characterized by accumulation of fat in the liver that can lead you to organ failure. Currently, the suggested treatment for NAFLD is decrease in fat intake associated with increase in physical activity. However, little is known about the most appropriate training protocols for the prevention or treatment of this disease. This study aims to examine the effects of exercise at the intensity of the 80% of anaerobic threshold (AT) on markers of NAFLD in obese rats. To induce obesity, 90 days old rats, will be maintained with a high fat / higher calorie diet (35% of animal fat / vegetable fat). Control rats will be treated with a balanced diet (AIN-93M). All animals will be submitted to the lactate minimum test to identify the anaerobic threshold (AT) during swimming exercise. Part of the animals from each group will be subjected to swimming training in intensity equivalent to 80% of the individual AT, 1 h / day, 5 days / week for 16 weeks, another part of them will have exercise training suspended after 8 weeks, remaining under observation for additional 8 weeks, while others will remain sedentary throughout the experiment. It was possible to standardize a protocol to determine the aerobic capacity to newborn rats, physical exercise performed from infancy up to 90 days of age helps in reducing weight gain, improves glucose metabolism and reduced hepatic fat accumulation. The detraining made that some metabolic improvements resulting from the exercise were neutralized, as well as weight gain. Based on this, it is concluded that regular exercise can be... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Physical education and training, Educação fisica, Obesidade, Gordura, Exercícios aeróbicos, Figado - Doenças
Como citar
MOURA, Leandro Pereira de. Treinamento aeróbio na prevenção da doença hepática não alcoólica decorrente da obesidade em ratos. 2013. 161. Dissertação - (mestrado) - Universidade Estadual Paulista, Instituto de Biociências de Rio Claro, 2013.