Avaliação dos fatores de risco para osteoporose em mulheres na pós-menopausa
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Data
2011-02-09
Autores
Buttros, Davi de Araújo Brito [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
Avaliar o perfil da densidade mineral óssea (DMO) e os fatores de risco associados à osteoporose na pós-menopausa. Realizou-se estudo clínico-transversal com 431 mulheres. Idade entre 40-75 anos, atendidas ambulatorialmente em Hospital Universitário. Incluíram-se mulheres com: amenorréia>12 meses e idade ≥45 anos ou, ooforectomia ≥40 anos, com valores de DMO (coluna lombar e colo de fêmur) pelo DEXA dos últimos 12 meses. Fatores de risco avaliados: idade, idade e tempo de menopausa, tabagismo, atividade física (30min/5x/sem), artrite reumatóide (AR), uso de corticoterapia e de terapia hormonal (TH), fratura prévia, fratura materna de quadril e índice de massa corpórea (IMC=peso/altura2). Valores séricos de cálcio, fosfatase alcalina (FA) e calciúria-24h foram analisados. Empregou-se teste do Qui-quadrado (variáveis categóricas) e método de regressão logística no risco (odds ratio-OR) para osteoporose. A média de idade foi 54,1 ± 6,9 anos, tempo de menopausa 7,5 ± 5,8 anos, IMC 28,2 ± 5,3kg/m2. Encontrou-se: usuárias de TH 35,9%, exercício regular 27,3%, tabagistas 23,8%, menopausa <40anos 18,1%, fratura prévia 11,8%, fratura materna de quadril 10,7%, corticoterapia 4,8%, AR 4,0%. Pelos critérios da OMS, 106 (24,6%) mulheres apresentavam osteoporose (T-escore≤-2,5DP), 188 (43,6%) osteopenia (-1,0/-2,4DP) e 137 (31,8%) eram normais (≥-1,0DP). Detectou-se osteoporose em 12% das mulheres com idade entre 40-49anos, 21,8% 50-59 anos e 45,7% >60 anos (p<0,001). Osteoporose ocorreu em 11,8% com tempo de menopausa <5anos, 29,4% de 6-10anos, e 41% >10anos (p<0,001). Naquelas com menopausa precoce, 80% apresentaram osteopenia/osteoporose (p=0,032) e com IMC<20kg/m2, 50% osteoporóticas (p<0,001). Nenhuma associação foi observada entre DMO e valores de cálcio (p=0,174), FA (p=0,901) e calciúria (p=0,759). O risco de detectar osteoporose aumentou com idade...
To evaluate bone mineral density (BMD) profiles and their risk factors associated with postmenopausal osteoporosis. A cross-sectional clinical study was performed on 431 women aged 40-75 years and cared for at the outpatient clinic of a University Hospital. Women showing the following characteristics were included: amenorrhea >12 months and age ≥ 45 years or, ooforectomy ≥ 40 years with BMD values (lumbar spine and femur neck) by DXA of the last 12 months. Risk factors evaluated: age, age and time of menopause, smoking, physical activity (30min/5x/week), rheumatoid arthritis (RA), use of corticotherapy and hormone therapy (HT), previous fracture, maternal hip fracture and body mass index (BMI=weight/height2). Serum values of calcium, alkaline phosphatase (AP) and 24-h urinary calcium were analyzed. The Chi-square test was used for categorical variables, and the logistic regression method (odds ratio-OR) was utilized for osteoporosis risk. Mean age was 54.1±6.9 years, menopausal period 7.5±5.8 years, BMI 28.2±5.3 kg/m2. The following were found: HT users 35.9%; regular exercise 27.3%; smokers 23.8%; menopause < 40 years 18.1%; low calcium intake (<400mg/day) 55.3%; previous fracture 11.8%; maternal fracture 10.7%, corticotherapy 4.8%, RA 4.0%. According to WHO criteria, 106 (24.6%) women showed osteoporosis (T- score ≤ -2.5 DP), 188 (43.6%) osteopenia (-1.0/-2.4 DP), and 137 (31.8%) were normal (≥ -1.0 DP). Osteoporosis was detected in 12% of the women aged 40-49 years, 21.8% 50-59 years and 45.7% > 60 years (p<0.001). Osteoporosis occurred to 11.8% with a menopause period < 5 years, 29.4% from 6 to 10 years, and 41% > 10 years (p<0.001). Of the women with early menopause, 80% showed osteopenia/osteoporosis (p=0.032), and of those with BMI < 20kg/m2, 50% were osteoporotic (p<0.001). No association was observed between BMD and calcium values (p=0.174), AP (p=0.901)... (Complete abstract click electronic access below)
To evaluate bone mineral density (BMD) profiles and their risk factors associated with postmenopausal osteoporosis. A cross-sectional clinical study was performed on 431 women aged 40-75 years and cared for at the outpatient clinic of a University Hospital. Women showing the following characteristics were included: amenorrhea >12 months and age ≥ 45 years or, ooforectomy ≥ 40 years with BMD values (lumbar spine and femur neck) by DXA of the last 12 months. Risk factors evaluated: age, age and time of menopause, smoking, physical activity (30min/5x/week), rheumatoid arthritis (RA), use of corticotherapy and hormone therapy (HT), previous fracture, maternal hip fracture and body mass index (BMI=weight/height2). Serum values of calcium, alkaline phosphatase (AP) and 24-h urinary calcium were analyzed. The Chi-square test was used for categorical variables, and the logistic regression method (odds ratio-OR) was utilized for osteoporosis risk. Mean age was 54.1±6.9 years, menopausal period 7.5±5.8 years, BMI 28.2±5.3 kg/m2. The following were found: HT users 35.9%; regular exercise 27.3%; smokers 23.8%; menopause < 40 years 18.1%; low calcium intake (<400mg/day) 55.3%; previous fracture 11.8%; maternal fracture 10.7%, corticotherapy 4.8%, RA 4.0%. According to WHO criteria, 106 (24.6%) women showed osteoporosis (T- score ≤ -2.5 DP), 188 (43.6%) osteopenia (-1.0/-2.4 DP), and 137 (31.8%) were normal (≥ -1.0 DP). Osteoporosis was detected in 12% of the women aged 40-49 years, 21.8% 50-59 years and 45.7% > 60 years (p<0.001). Osteoporosis occurred to 11.8% with a menopause period < 5 years, 29.4% from 6 to 10 years, and 41% > 10 years (p<0.001). Of the women with early menopause, 80% showed osteopenia/osteoporosis (p=0.032), and of those with BMI < 20kg/m2, 50% were osteoporotic (p<0.001). No association was observed between BMD and calcium values (p=0.174), AP (p=0.901)... (Complete abstract click electronic access below)
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Hormone therapy
Como citar
BUTTROS, Davi de Araújo Brito. Avaliação dos fatores de risco para osteoporose em mulheres na pós-menopausa. 2011. 49 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2011.