Response from Varani et al. to “Comment on ‘the IS6 family, a clinically important group of insertion sequences including IS26’ by Ruth M. Hall”

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dc.contributor.authorVarani, Alessandro [UNESP]
dc.contributor.authorHe, Susu
dc.contributor.authorSiguier, Patricia
dc.contributor.authorRoss, Karen
dc.contributor.authorChandler, Michael
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionMedical School of Nanjing University
dc.contributor.institutionCNRS - Laboratoire de Microbiologie et Génétique Moléculaires
dc.contributor.institutionGeorgetown University Medical Center
dc.date.accessioned2022-04-28T19:48:55Z
dc.date.available2022-04-28T19:48:55Z
dc.date.issued2022-12-01
dc.description.abstractThe IS6 family of insertion sequences is a large but coherent group which was originally named to avoid confusion between a number of identical or nearly identical IS that were identified at about the same time and given different names (IS15D, IS26, IS46, IS140, IS160, IS176). The underlying common mechanistic feature of all IS6 family members which have been investigated is that they appear to transpose by replicative transposition and form pseudo compound transposons with the flanking IS in direct repeat and in which associated genes are simply transferred to the target replicon and lost from the donor. In the accompanying letter Hall raises a number of very serious and wide-ranging criticisms of our recent review article concerning the IS6 family of insertion sequences. She clearly feels that we have undervalued her work and that we question or ignore certain of her in vivo results. This impression is almost certainly the result of the standard of proof we generally apply to mechanistic aspects of transposition where we think it important to identify transposition intermediates including the types of synaptic, strand cleavage and strand transfer complexes involved.en
dc.description.affiliationSchool of Agricultural and Veterinary Sciences Universidade Estadual Paulista, Sao Paulo
dc.description.affiliationState Key Laboratory of Pharmaceutical Biotechnology Medical School of Nanjing University, Jiangsu
dc.description.affiliationCentre de Biologie Intégrative-Université Paul SABATIER CNRS - Laboratoire de Microbiologie et Génétique Moléculaires, UMR 5100 - bât. CNRS-IBCG
dc.description.affiliationDepartment of Biochemistry Molecular and Cellular Biology Protein Information Resource Georgetown University Medical Center
dc.description.affiliationDepartment of Biochemistry Molecular and Cellular Biology Georgetown University Medical Center
dc.description.affiliationUnespSchool of Agricultural and Veterinary Sciences Universidade Estadual Paulista, Sao Paulo
dc.identifierhttp://dx.doi.org/10.1186/s13100-021-00258-8
dc.identifier.citationMobile DNA, v. 13, n. 1, 2022.
dc.identifier.doi10.1186/s13100-021-00258-8
dc.identifier.issn1759-8753
dc.identifier.scopus2-s2.0-85122195313
dc.identifier.urihttp://hdl.handle.net/11449/223153
dc.language.isoeng
dc.relation.ispartofMobile DNA
dc.sourceScopus
dc.titleResponse from Varani et al. to “Comment on ‘the IS6 family, a clinically important group of insertion sequences including IS26’ by Ruth M. Hall”en
dc.typeCarta

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