Social defeat stress in rats: escalation of cocaine and speedball binge self-administration, but not heroin

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dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorQuadros, Isabel M.
dc.contributor.authorHogenelst, Koen
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorMiczek, Klaus A.
dc.contributor.institutionTufts Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:01Z
dc.date.available2014-05-20T13:25:01Z
dc.date.issued2011-05-01
dc.description.abstractExposure to intermittent episodes of social defeat stress can increase drug seeking and leads to intense drug taking in rats.This study investigated the consequences of repeated, intermittent social defeat stress on patterns of drug self-administration in rats with access to heroin, cocaine, or a heroin-cocaine combination (speedball).Male Long-Evans rats were either handled (controls) or subjected to 25-min social defeat stress episodes on days 1, 4, 7, and 10 during confrontations with an aggressive resident. Ten days following the last defeat, rats were assessed for locomotor cross-sensitization in response to heroin or cocaine. Animals were then prepared with intrajugular catheters for drug self-administration. Separate groups of controls and defeated rats were examined for self-administration of heroin (experiment 1), a heroin-cocaine combination (experiment 2), or cocaine (experiment 3). Drug self-administration patterns were evaluated using fixed or progressive ratio schedules of reinforcement during limited access sessions or a 24-h unlimited access binge.Rats with a history of intermittent social defeat stress showed sensitized locomotor behavior when challenged with heroin or cocaine relative to controls. During the 24-h binge session, defeated rats escalated cocaine-taking behavior (ca. 110 mg/kg vs. 66 mg/kg in controls), persisted in self-administering cocaine or the heroin-cocaine mixture for more hours, and showed a tendency for increased heroin-cocaine intake, but no effects on heroin taking.A history of social defeat stress seems to preferentially promote escalated intake of cocaine but not heroin, unless a heroin-cocaine combination is available.en
dc.description.affiliationTufts Univ, Dept Psychol, Medford, MA 02155 USA
dc.description.affiliationUNESP São Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationTufts Univ, Sch Med, Dept Psychiat, Boston, MA 02111 USA
dc.description.affiliationTufts Univ, Sch Med, Dept Pharmacol, Boston, MA 02111 USA
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP, Brazil
dc.format.extent165-175
dc.identifierhttp://dx.doi.org/10.1007/s00213-010-2139-6
dc.identifier.citationPsychopharmacology. New York: Springer, v. 215, n. 1, p. 165-175, 2011.
dc.identifier.doi10.1007/s00213-010-2139-6
dc.identifier.issn0033-3158
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/7914
dc.identifier.wosWOS:000289293000015
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPsychopharmacology
dc.relation.ispartofjcr3.222
dc.relation.ispartofsjr1,494
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAddictionen
dc.subjectIntravenous self-administrationen
dc.subjectOpiateen
dc.subjectPsychostimulanten
dc.subjectLocomotor sensitizationen
dc.subjectStressen
dc.subjectCocaineen
dc.titleSocial defeat stress in rats: escalation of cocaine and speedball binge self-administration, but not heroinen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes2514762545280942[4]
unesp.author.orcid0000-0002-5200-2214[2]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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