Effects of a probiotic soy product and physical exercise on formation of pre-neoplastic lesions in rat colons in a short-term model of carcinogenic

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dc.contributor.authorSilva, Maicon F. [UNESP]
dc.contributor.authorSivieri, Katia [UNESP]
dc.contributor.authorRossi, Elizeu Antonio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:43Z
dc.date.available2014-05-20T13:23:43Z
dc.date.issued2009-08-06
dc.description.abstractPurpose: In this study the influence of moderate or intense physical exercise, alone or in combination with the consumption of a soya product fermented with Enterococcus faecium, on the development of colon cancer induced chemically in rats with 1,2-dimethylhydrazine (DMH), was investigated.Methods: Eighty male Wistar SPF rats were randomly allocated to 8 groups (n = 10). One week after the start of the program of product ingestion and/or physical activity, all animals except the controls (group I) were injected subcutaneously with 50 mg/kg b.w. of 1,2-dimethylhydrazine (DMH). This procedure was repeated at the end of the second week. At the end of the 6-week experiment, all the animals were euthanized; the colons were removed and numbers of ACF was estimated.Results: Twenty-four days after the induction of pre-neoplastic lesions, it was evident that the formation of ACF was not significantly reduced by the ingestion of the fermented product, by intense or moderate physical activity or by a combination of these factors, in comparison with the positive control group of rats (p < 0.05). on the other hand, the performance of intense exercise, on its own, increased the number of ACF.Conclusion: The results reported in this article show that consumption of the fermented soy product described here and the practice of physical exercise (intense or moderate) were incapable, separately or combined, of inhibiting the formation of ACF in DMH-induced rats. The intense physical exercise led to an increased number of foci in the colons of these rats and, probably, to greater susceptibility to colorectal cancer.en
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Food & Nutr, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Food & Nutr, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent6
dc.identifierhttp://dx.doi.org/http://dx.doi.org/10.1186/1550-2783-6-17
dc.identifier.citationJournal of The International Society of Sports Nutrition. London: Biomed Central Ltd., v. 6, p. 6, 2009.
dc.identifier.doi10.1186/1550-2783-6-17
dc.identifier.fileWOS000269286300001.pdf
dc.identifier.issn1550-2783
dc.identifier.lattes3242858535763793
dc.identifier.urihttp://hdl.handle.net/11449/7205
dc.identifier.wosWOS:000269286300001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofJournal of the International Society of Sports Nutrition
dc.relation.ispartofjcr3.135
dc.relation.ispartofsjr0,775
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleEffects of a probiotic soy product and physical exercise on formation of pre-neoplastic lesions in rat colons in a short-term model of carcinogenicen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
unesp.author.lattes3242858535763793
unesp.author.orcid0000-0001-8632-1478[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Alimentos e Nutrição - FCFAR