Sistemas para liberação colônica: Uma alternativa para a veiculação de fármacos para efeito local ou sistêmico

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dc.contributor.authorLucinda-Silva, Ruth Meri [UNESP]
dc.contributor.authorEvangelista, Raul Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:22Z
dc.date.available2014-05-27T11:20:22Z
dc.date.issued2001-12-01
dc.description.abstractProblems related to the systemic administration of drugs, such as biodistribution, difficulty of targeting, necessity of high doses to achieve adequate levels of the drug in specific sites, toxicity, and undesirable side effects have lead to the development of systems able to direct the drug to specific sites in the body. Among the possible organs to the targeting of drugs, the colon can be used for local and systemic therapies. By developing such systems some models have been tested, using pH dependent release, release controlled by enzymatic degradation, time controlled release systems and pressure controlled release systems. This review presents an overview of the colonic release of drugs and the strategies used to achieve such targeting.en
dc.description.affiliationProg. Pos-graduacao Cie. Farmaceut. Faculdade de Ciencias Farmaceuticas UNESP, 14802 902 Araraquara - SP
dc.description.affiliationUnespProg. Pos-graduacao Cie. Farmaceut. Faculdade de Ciencias Farmaceuticas UNESP, 14802 902 Araraquara - SP
dc.format.extent11-28
dc.identifier.citationRevista de Ciencias Farmaceuticas, v. 22, n. 1, p. 11-28, 2001.
dc.identifier.issn0101-3793
dc.identifier.lattes5361569184579557
dc.identifier.scopus2-s2.0-0035552064
dc.identifier.urihttp://hdl.handle.net/11449/66730
dc.language.isopor
dc.relation.ispartofRevista de Ciencias Farmaceuticas
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectColonic release
dc.subjectDrug controlled release systems
dc.subjectDrug targeting
dc.subjectamylase
dc.subjectbeta galactosidase
dc.subjectbeta glucosidase
dc.subjecteudragit
dc.subjectglycosidase
dc.subjectmesalazine
dc.subjectolsalazine
dc.subjectpolygalacturonase
dc.subjectsalazosulfapyridine
dc.subjectxylan 1,4 beta xylosidase
dc.subjectxylan endo 1,3 beta xylosidase
dc.subjectchronic inflammation
dc.subjectcolon absorption
dc.subjectcontrolled drug release
dc.subjectdrug binding site
dc.subjectdrug delivery system
dc.subjectdrug distribution
dc.subjectdrug megadose
dc.subjectdrug release
dc.subjectdrug specificity
dc.subjectdrug targeting
dc.subjectenteritis
dc.subjectenzyme degradation
dc.subjecthuman
dc.subjectpH
dc.subjectpressure measurement
dc.subjectside effect
dc.titleSistemas para liberação colônica: Uma alternativa para a veiculação de fármacos para efeito local ou sistêmicopt
dc.title.alternativeColonic release systems: An alternative to carry drugs for topical or systemic effecten
dc.typeArtigo
unesp.author.lattes5361569184579557
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR