Síntese e caracterização de nanofibras de PCL associada ao biovidro e PCL associada ao biovidro dopado com magnésio e lítio
Data
2024-03-06
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Universidade Estadual Paulista (Unesp)
Resumo
Objetivo: O estudo teve por finalidade sintetizar e caracterizar morfológica e físico-quimicamente nanofibras de PCL associada ao biovidro e nanofibras de PCL associada ao biovidro dopado com íons magnésio e lítio, a fim de analisar se houve influência dos íons no resultado morfológico das fibras produzidas e definir a melhor associação de parâmetros para a otimização da produção. Material e Métodos: Para a síntese das fibras, três soluções foram preparadas a partir da dissolução de 0,4 g de PCL em 2 mL de acetona e ficaram sob agitação constante em um agitador magnético por 24h. Após a dissolução, foi acrescentado 6% em massa de biovidro produzido pela rota sol-gel precipitado, uma solução contendo biovidro dopado com Mg e outra solução contendo biovidro dopado com Li e ficaram sob agitação até total dissolução. Após a dissolução total, a solução foi colocada em uma seringa de plástico com agulha de ponta reta de 0,7 mmØ e submetida ao processo de eletrofiação sob alguns parâmetros que foram alternados como fluxo (1,5 e 2 mLh-1), distância (10, 12 e 15 cm) e voltagem (10, 12 e 15 kV). As membranas produzidas foram caracterizadas por MEV, DRX, EDS, FTIR e Goniometria. Resultados: Com base nos resultados obtidos foi possível observar que as fibras obtidas através da associação dos parâmetros resultaram em produção de fibras satisfatórias e com ausência de defeitos. Conclusão: Considerando os resultados obtidos, foi possível sintetizar e caracterizar os biomateriais, assim como encontrar os melhores parâmetros de eletrofiação em cada grupo.
Objective: The study aimed to synthesize and characterize morphologically and physicochemically PCL nanofibers associated with bioglass and PCL nanofibers associated with magnesium and lithium-doped bioglass, in order to analyze whether the ions influenced the morphological outcome of the produced fibers and to define the best parameter association for production optimization. Material and Methods: For fiber synthesis, three solutions were prepared by dissolving 0.4 g of PCL in 2 mL of acetone and were continuously stirred on a magnetic stirrer for 24 hours. After dissolution, 6% by mass of bioglass produced by the sol-gel Precipitation route was added, one solution containing Mg-doped bioglass and another solution containing Li-doped bioglass, and they were stirred until complete dissolution. After complete dissolution, the solution was placed in a plastic syringe with a straight tip needle of 0.7mmØ and subjected to the electrospinning process under several parameters that were alternated, such as flow rate (1.5 and 2 mLh-1), distance (10, 12, and 15 cm), and voltage (10, 12, and 15 kV). The produced membranes were characterized by SEM, XRD, EDS, FTIR, and Goniometry. Results: Based on the obtained results, it was possible to observe that the fibers obtained by the combination of parameters resulted in satisfactory fiber production with an absence of defects. Conclusion: Considering the obtained results, it was feasible to synthesize and characterize the biomaterials, as well as determine the best electrospinning parameters in each group.
Objective: The study aimed to synthesize and characterize morphologically and physicochemically PCL nanofibers associated with bioglass and PCL nanofibers associated with magnesium and lithium-doped bioglass, in order to analyze whether the ions influenced the morphological outcome of the produced fibers and to define the best parameter association for production optimization. Material and Methods: For fiber synthesis, three solutions were prepared by dissolving 0.4 g of PCL in 2 mL of acetone and were continuously stirred on a magnetic stirrer for 24 hours. After dissolution, 6% by mass of bioglass produced by the sol-gel Precipitation route was added, one solution containing Mg-doped bioglass and another solution containing Li-doped bioglass, and they were stirred until complete dissolution. After complete dissolution, the solution was placed in a plastic syringe with a straight tip needle of 0.7mmØ and subjected to the electrospinning process under several parameters that were alternated, such as flow rate (1.5 and 2 mLh-1), distance (10, 12, and 15 cm), and voltage (10, 12, and 15 kV). The produced membranes were characterized by SEM, XRD, EDS, FTIR, and Goniometry. Results: Based on the obtained results, it was possible to observe that the fibers obtained by the combination of parameters resulted in satisfactory fiber production with an absence of defects. Conclusion: Considering the obtained results, it was feasible to synthesize and characterize the biomaterials, as well as determine the best electrospinning parameters in each group.
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Materiais biocompatíveis, Microscopia eletrônica de varredura, Regeneração óssea, Coated materials, Scanning electron microscopy, Bone regeneration