Kaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma in Brazil

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dc.contributor.authorRamos-da-Silva, S. [UNESP]
dc.contributor.authorElgui-de-Oliveira, D. [UNESP]
dc.contributor.authorBorges, L. [UNESP]
dc.contributor.authorBacchi, C. E.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionConsultoria em Patologia
dc.date.accessioned2014-05-27T11:21:51Z
dc.date.available2014-05-27T11:21:51Z
dc.date.issued2006-05-01
dc.description.abstractKaposi's sarcoma (KS) became a critical health issue with the emergence of acquired immunodeficiency syndrome (AIDS) in the 1980s. Four clinical-epidemiological forms of KS have been described: classical KS, endemic KS,iatrogenic KS, and AIDS-associated KS. In 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 was identified by Chang and colleagues, and has been detected worldwide at frequencies ranging from 80 to 100%. The aim of the present study was to evaluate the frequency of KSHV infection in KS lesions from HIV-positive and HIV-negative patients in Brazil, as well as to review the current knowledge about KS transmission and detection. For these purposes, DNA from 51 cases of KS was assessed by PCR: 20 (39.2%) cases of classical KS, 29 (56.9%) of AIDS-associated KS and 2 (3.9%) of iatrogenic KS. Most patients were males (7.5:1, M/F), and mean age was 47.9 years (SD = ± 18.7 years). As expected, HIV-positive KS patients were younger than patients with classical KS. On the other hand, patients with AIDS-associated KS have early lesions (patch and plaque) compared to classical KS patients (predominantly nodular lesions). This is assumed to be the result of the early diagnose of KS in the HIV-positive setting. KSHV infection was detected by PCR in almost all cases (48/51; 94.1%), irrespectively of the clinical-epidemiological form of KS. These results show that KSHV is associated with all forms of KS in Brazilian patients, a fact that supports the role of this virus in KS pathogenesis. © 2006 Brazilian Journal of Medical and Biological Research.en
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina de Botucatu Universidade Estatual Paulista, Botucatu, SP
dc.description.affiliationConsultoria em Patologia, Botucatu, SP
dc.description.affiliation, Rua Major Leonidas Cardoso, 739, 18602-010 Botucatu, SP
dc.description.affiliationUnespDepartamento de Patologia Faculdade de Medicina de Botucatu Universidade Estatual Paulista, Botucatu, SP
dc.format.extent573-580
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2006000500002
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 39, n. 5, p. 573-580, 2006.
dc.identifier.doi10.1590/S0100-879X2006000500002
dc.identifier.file2-s2.0-33646416752.pdf
dc.identifier.issn0100-879X
dc.identifier.issn1678-4510
dc.identifier.orcid0000-0001-5562-9648
dc.identifier.scieloS0100-879X2006000500002
dc.identifier.scopus2-s2.0-33646416752
dc.identifier.urihttp://hdl.handle.net/11449/68870
dc.identifier.wosWOS:000237790100002
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBrazil
dc.subjectHuman herpesvirus type 8
dc.subjectKaposi's sarcoma
dc.subjectKaposi's sarcoma-associated herpesvirus
dc.subjectPolymerase chain reaction
dc.subjectViral carcinogenesis
dc.subjectDNA
dc.subjectadolescent
dc.subjectadult
dc.subjectage distribution
dc.subjectcancer staging
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease classification
dc.subjectDNA determination
dc.subjectearly diagnosis
dc.subjectepidemic
dc.subjectfemale
dc.subjectfrequency analysis
dc.subjectherpes
dc.subjecthuman
dc.subjectHuman herpesvirus 8
dc.subjectHuman immunodeficiency virus infection
dc.subjecthuman tissue
dc.subjectKaposi sarcoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpathophysiology
dc.subjectpolymerase chain reaction
dc.subjectskin biopsy
dc.subjectvirus genome
dc.subjectvirus identification
dc.subjectvirus transmission
dc.subjectAIDS-Related Opportunistic Infections
dc.subjectAmino Acid Sequence
dc.subjectDNA, Viral
dc.subjectFemale
dc.subjectGenome, Viral
dc.subjectHerpesvirus 8, Human
dc.subjectHumans
dc.subjectMale
dc.subjectMolecular Sequence Data
dc.subjectPolymerase Chain Reaction
dc.subjectSarcoma, Kaposi
dc.subjectHerpes
dc.subjectHerpesviridae
dc.subjectHuman immunodeficiency virus
dc.titleKaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma in Brazilen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm
unesp.author.orcid0000-0001-5562-9648[2]
unesp.author.orcid0000-0002-0768-8421[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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