Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients

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dc.contributor.authorKunzmann, Andrew T.
dc.contributor.authorProença, Marcela Alcântara [UNESP]
dc.contributor.authorJordao, Haydee Wt
dc.contributor.authorJiraskova, Katerina
dc.contributor.authorSchneiderova, Michaela
dc.contributor.authorLevy, Miroslav
dc.contributor.authorLiska, Václav
dc.contributor.authorBuchler, Tomas
dc.contributor.authorVodickova, Ludmila
dc.contributor.authorVymetalkova, Veronika
dc.contributor.authorSilva, Ana Elizabete [UNESP]
dc.contributor.authorVodicka, Pavel
dc.contributor.authorHughes, David J.
dc.contributor.institutionQueen’s University Belfast
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCharles University
dc.contributor.institutionInstitute of Experimental Medicine of the Czech Academy of Sciences
dc.contributor.institutionGeneral University Hospital in Prague
dc.contributor.institutionCharles University and Thomayer Hospital
dc.contributor.institutionUniversity College Dublin
dc.date.accessioned2019-10-06T17:16:30Z
dc.date.available2019-10-06T17:16:30Z
dc.date.issued2019-01-01
dc.description.abstractThere is increasing evidence indicating a role for Fusobacterium nucleatum (F. nucleatum) in colorectal cancer (CRC) development and prognosis. This study evaluated F. nucleatum as a prognostic biomarker, by assessing its association with post-diagnosis survival from CRC. From September 2008 to April 2012 CRC patients (n = 190) were recruited from three hospitals within the Czech Republic. F. nucleatum DNA copies were measured in adjacent non-malignant and colorectal tumor tissues using quantitative real-time PCR. Cox Proportional Hazards (HR) models were applied to evaluate the association between F. nucleatum DNA and overall survival, adjusting for key confounders. Risk prediction modeling was conducted to evaluate the ability to predict survival based on F. nucleatum status. High, compared with low, levels of F. nucleatum in colorectal tumor tissues were associated with poorer overall survival (adjusted HR 1.68, 95% CI 1.02–2.77), which was slightly attenuated after additional adjustment for microsatellite instability status. However, inclusion of F. nucleatum in risk prediction models did not improve the ability to identify patients who died beyond known prognostic factors such as disease pathology staging. Although the increased presence of F. nucleatum was associated with poorer prognosis in CRC patients, this may have limited clinical relevance as a prognostic biomarker.en
dc.description.affiliationCentre for Public Health Queen’s University Belfast
dc.description.affiliationDepartment of Biology São Paulo State University UNESP
dc.description.affiliationInstitute of Biology and Medical Genetics First Faculty of Medicine Charles University
dc.description.affiliationDepartment of Molecular Biology of Cancer Institute of Experimental Medicine of the Czech Academy of Sciences
dc.description.affiliationDepartment of Surgery General University Hospital in Prague
dc.description.affiliationDepartment of Surgery First Faculty of Medicine Charles University and Thomayer Hospital
dc.description.affiliationBiomedical Centre Faculty of Medicine in Pilsen Charles University
dc.description.affiliationDepartment of Oncology First Faculty of Medicine Charles University and Thomayer Hospital
dc.description.affiliationCancer Biology and Therapeutics Group School of Biomolecular and Biomedical Science UCD Conway Institute University College Dublin
dc.description.affiliationUnespDepartment of Biology São Paulo State University UNESP
dc.identifierhttp://dx.doi.org/10.1007/s10096-019-03649-1
dc.identifier.citationEuropean Journal of Clinical Microbiology and Infectious Diseases.
dc.identifier.doi10.1007/s10096-019-03649-1
dc.identifier.issn1435-4373
dc.identifier.issn0934-9723
dc.identifier.scopus2-s2.0-85069950591
dc.identifier.urihttp://hdl.handle.net/11449/190541
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Clinical Microbiology and Infectious Diseases
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBacterial infection
dc.subjectColorectal cancer
dc.subjectColorectal neoplasm
dc.subjectDisease survival
dc.subjectFusobacterium nucleatum
dc.titleFusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patientsen
dc.typeArtigo
unesp.author.lattes2503906319038306[11]
unesp.author.orcid0000-0003-1668-8770[13]
unesp.author.orcid0000-0003-1491-8878[11]

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