Dendrimers as potential platform in nanotechnology-based drug delivery systems

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dc.contributor.authorSilva Júnior, Nelson
dc.contributor.authorMenacho, F. P.
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Educação e Meio Ambiente (FAEMA)
dc.date.accessioned2016-01-28T16:56:33Z
dc.date.available2016-01-28T16:56:33Z
dc.date.issued2012
dc.description.abstractThe dendrimers of poly (amidoamine) (PAMAM) are nanoparticles which have proven succeed in transporting drugs due to high solubility, low toxicity and ability to control drugs release. Studies have explored the biological potential of dendrimers such as to transport genes, development of vaccines, antiviral, antibacterial and anticancer therapies. This review of literature on the PAMAM dendrimers discusses the architecture and general construction of dendrimers and intrinsic properties of the PAMAM. This study also describes how the PAMAM interact with many drugs and the potential of these macromolecules as well as drug nanocarriers in transdermal routes of administration, ocular, respiratory, oral and intravenous administration. Dendrimers promises good future prospects for the biomedicine.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Departamento de Fármacos e Medicamentos, Araraquara, Rodovia Araraquara-Jaú, km 1, Campus, CEP 14081-902, SP, Brasil
dc.description.affiliationEnviromental and Educational Faculty FAEMA, Av. Machadinho, 4349, CEP: 78932-000, Ariquemes, RO, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Departamento de Fármacos e Medicamentos, Araraquara, Rodovia Araraquara-Jaú, km 1, Campus, CEP 14081-902, SP, Brasil
dc.format.extent23-30
dc.identifierhttp://www.iosrphr.org/pages/volume2-issue5(part-6).html
dc.identifier.citationIOSR Journal of Pharmacy, v. 2, n. 5, p. 23-30, 2012.
dc.identifier.issn2250-3013
dc.identifier.lattes1427125996716282
dc.identifier.urihttp://hdl.handle.net/11449/133771
dc.language.isoeng
dc.relation.ispartofIOSR Journal of Pharmacy
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectDendrimersen
dc.subjectNanocarriersen
dc.subjectPAMAM Poly (amidoamine)en
dc.subjectPharmaceutical applicationen
dc.titleDendrimers as potential platform in nanotechnology-based drug delivery systemsen
dc.typeArtigo
unesp.author.lattes1427125996716282
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentDepartamento de Fármacos e Medicamentospt

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