Efectos de la asociación de estatina y del ejercicio aeróbico en los cardiomiocitos de rata. Estudio Morfométrico

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dc.contributor.authorPadulla, Susimary Aparecida Trevizan [UNESP]
dc.contributor.authorAzoubel, Reinaldo [UNESP]
dc.contributor.authorBonfim, Mariana Rotta
dc.contributor.authorAccioly, Marilita Falângola
dc.contributor.authorCamargo Filho, José Carlos Silva [UNESP]
dc.contributor.authorPadovani, João Armando [UNESP]
dc.contributor.authorBrandão, Antônio Carlos [UNESP]
dc.contributor.authorSouza, Dorotéia Rossi Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of São José do Rio Preto
dc.date.accessioned2022-04-29T08:47:54Z
dc.date.available2022-04-29T08:47:54Z
dc.date.issued2009-01-01
dc.description.abstractPhysical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingestion, a blood collection was made to verify the dyslipidaemia. Simvastatin (20 mg) was taken five days a week, during eight weeks. During this period, the animals exercised 60 minutes daily in the treadmill. After the last day of the protocol, the cardiac muscle was collected and maintained in liquid nitrogen (-180°C); the cuts were stained by Hematoxilin-Eosin method, and the cardiac fibers were submitted to the nuclear morphometric analyses. The data were analyzed using descriptive analyses, paired T test, Kruskal-Wallis test and Dunn post hoc test; for all analyses, it was adopted p<0.05. It was verified that the group receiving statin presented values statistically significant in comparison to the other groups, in the tridimensional and linear variables. The exercised and statin group, the values obtained in the morphometric analyses were similar to the control group. It is suggested that statins alone can cause alterations in the nucleus of cardiac cells that can be related to apoptosis occurrence and, when exercise is practiced associated to statin administration, the effects of statin can be reduced, what can be related to beneficial adaptations of cardiac mitochondrial in response to physical exercise, turning them more resistant to apoptotic stimuli.en
dc.description.affiliationPhysiotherapy Department São Paulo State University
dc.description.affiliationUniversity of São José do Rio Preto
dc.description.affiliationSão Paulo State University
dc.description.affiliationUnespPhysiotherapy Department São Paulo State University
dc.description.affiliationUnespSão Paulo State University
dc.format.extent83-88
dc.identifierhttp://dx.doi.org/10.4067/S0717-95022009000100015
dc.identifier.citationInternational Journal of Morphology, v. 27, n. 1, p. 83-88, 2009.
dc.identifier.doi10.4067/S0717-95022009000100015
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.scopus2-s2.0-68249147714
dc.identifier.urihttp://hdl.handle.net/11449/231880
dc.language.isospa
dc.relation.ispartofInternational Journal of Morphology
dc.sourceScopus
dc.subjectCardiomyocite nuclei
dc.subjectExercise
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors
dc.titleEfectos de la asociación de estatina y del ejercicio aeróbico en los cardiomiocitos de rata. Estudio Morfométricoes
dc.title.alternativeEffects of statin and aerobic physical exercise association in the cardiomyocytes of the rat. morphometric studyen
dc.typeArtigo

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