Chemopreventive effects of a Tamarindus indica fruit extract against colon carcinogenesis depends on the dietary cholesterol levels in hamsters

Página do item simplificado
dc.contributor.authorMartinello, Flavia
dc.contributor.authorKannen, Vinicius
dc.contributor.authorFranco, Joao Jose
dc.contributor.authorGasparotto, Bianca
dc.contributor.authorSakita, Juliana Yumi
dc.contributor.authorSugohara, Atushi [UNESP]
dc.contributor.authorGarcia, Sergio Britto
dc.contributor.authorUyemura, Sergio Akira
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-28T17:42:15Z
dc.date.available2018-11-28T17:42:15Z
dc.date.issued2017-09-01
dc.description.abstractTamarind has significant antioxidant potential. We showed that tamarind protects hypercholesterolemic hamsters from atherosclerosis. Hypercholesterolemia might increase the risk of colon cancer. We investigated whether tamarind extract modulates the risk of colon cancer in hypercholesterolemic hamsters. Hamsters (n = 64) were given tamarind and a hypercholesterolemic diet for 8 weeks. The groups were the control, tamarind treatment, hypercholesterolemic, and hypercholesterolemic treated with tamarind groups. Half of each group was exposed to the carcinogen dimethylhydrazine (DMH) at the 8th week. All hamsters were euthanatized at the 10th week. In carcinogen-exposed hypercholesterolemic hamsters, tamarind did not alter the cholesterol or triglyceride serum levels, but it reduced biomarkers of liver damage (alanine transaminase [ALT], and aspartate aminotransferase [AST]). Tamarind decreased DNA damage in hepatocytes, as demonstrated by analysis with an anti-gamma H2A.X antibody. In liver and serum samples, we found that this fruit extract reduced lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) and increased endogenous antioxidant mechanisms (glutathione peroxidase [GPx] and superoxide dismutase [SOD]). However, tamarind did not alter either lipid per oxidation or antioxidant defenses in the colon, which contrasts with DMH exposure. Moreover, tamarind significantly increased the stool content of cholesterol. Although tamarind reduced the risk of colon cancer in hypercholesterolemic hamsters that were carcinogenically exposed to DMH by 63.8% (Metallothionein), it was still similar to 51% higher than for animals fed a regular diet. Staining colon samples with an anti-gamma H2A.X antibody confirmed these findings. We suggest that tamarind has chemoprotective activity against the development of colon carcinogenesis, although a hypercholesterolemic diet might impair this protection. (C) 2017 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Santa Catarina, Dept Clin Anal, Florianopolis, SC, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Toxicol Bromatol & Clin Anal, BR-14040903 Ribeirao Preto, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Anim Sci, Jaboticabal, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Pathol, Ribeirao Preto, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Anim Sci, Jaboticabal, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 02/03174-5
dc.description.sponsorshipIdCNPq: 475276/01-9
dc.format.extent261-269
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2017.07.005
dc.identifier.citationFood And Chemical Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 107, p. 261-269, 2017.
dc.identifier.doi10.1016/j.fct.2017.07.005
dc.identifier.fileWOS000407982900026.pdf
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/11449/165708
dc.identifier.wosWOS:000407982900026
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood And Chemical Toxicology
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectLipid peroxidation
dc.subjectOxidative stress
dc.subjectCholesterol
dc.subjectTamarind
dc.subjectHypercholesterolemia
dc.subjectAntioxidant potential
dc.titleChemopreventive effects of a Tamarindus indica fruit extract against colon carcinogenesis depends on the dietary cholesterol levels in hamstersen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0001-6290-8063[2]

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000407982900026.pdf
Tamanho:
1.16 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar

Coleções

Artigos - Zootecnia - FCAV