Potencial protetor da associação de fluoretos com o biopolímero aminometacrilato na erosão inicial: estudo in situ cruzado randomizado
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Data
2024-03-07
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Universidade Estadual Paulista (Unesp)
Resumo
O objetivo desse estudo randomizado, cruzado e in situ foi avaliar o potencial antierosivo de soluções fluoretadas associadas ao biopolímero aminometacrilato sobre o esmalte. Doze voluntários instalaram um dispositivo intraoral contendo espécimes de esmalte bovino. Após 5 min, realizaram o bochecho (1 min) com uma das soluções testadas: Água ultrapura (C); Flúor (F, 225ppm F-); Cloreto Estanhoso (S, 800ppm Sn+2); Aminometacrilato (AMC, 2%); FS; AMC+F; AMC+FS e permaneceram por 30 min com o dispositivo para permitir a maturação da película adquirida. Os espécimes foram então submetidos ao desafio com ácido clorídrico 0,03%, pH 2,3, 3 min extra oralmente. Esses passos foram repetidos 5 vezes. Cada solução foi testada em fase distinta com os mesmos voluntários, com intervalo 2 dias de washout. Os espécimes foram submetidos à análise da microdureza superficial Knoop antes e após a ciclagem, para o cálculo do percentual de redução da microdureza (%KHNred). Adicionalmente, foi determinada a concentração de flúor solúvel em KOH (µg/cm²) na superfície dos espécimes. Os dados foram analisados com RM-ANOVA e Tukey (5%). Os valores médios de %KHNred foram: C (-37,7 ± 4,6)A, S (-37,8 ± 4,9)A, AMC (-26,8 ± 2,5)B, F (-31,0 ± 3,4)B, FS (-30,3 ± 5,0)B, AMC+F (-21,0 ± 4,9)C, AMC+FS (-19,3 ± 4,1)C. Os resultados de concentração de flúor solúvel em KOH foram: C = S = AMC < F < AMC+F ≤ AMC+FS ≤ FS. Concluiu-se que o biopolímero AMC aumentou efeito antierosivo do flúor associado ou não ao estanho na presença da película adquirida sobre o esmalte.
The objective of this randomized, crossover and in situ study was to evaluate the anti-erosion potential of fluoride solutions associated with aminomethacrylate biopolymer on enamel. Twelve volunteers installed an intraoral device containing bovine enamel specimens. After 5 min, they performed the mouthwash (1 min) with one of the tested solutions: Ultrapure water (C); Fluorine (F, 225ppm F-); Stannous Chloride (S, 800ppm Sn+2); Aminomethacrylate (AMC, 2%); FS; AMC+F; AMC+FS and remained for 30 min with the device to allow maturation of the acquired pellicle. The specimens were then challenged with 0.03% hydrochloric acid, pH 2.3, 3 min extra orally. These steps were repeated 5 times. Each solution was tested in a different phase with the same volunteers, with a 2-day washout interval. The specimens were subjected to Knoop surface microhardness analysis before and after cycling, to calculate the percentage of microhardness reduction (%KHNred). Additionally, the concentration of fluorine soluble in KOH (µg/cm²) on the surface of the specimens was determined. Data were analyzed with RM-ANOVA and Tukey (5%). The mean %KHNred values were: C (-37.7 ± 4.6)A, S (-37.8 ± 4.9)A, AMC (-26.8 ± 2.5)B, F (- 31.0 ± 3.4)B, FS (-30.3 ± 5.0)B, AMC+F (-21.0 ± 4.9)C, AMC+FS (-19.3 ± 4.1) )W. The KOH-soluble fluorine concentration results were: C = S = AMC < F < AMC+F ≤ AMC+FS ≤ FS. It was concluded that the AMC biopolymer increased the anti-erosion effect of fluorine associated or not with tin in the presence of the acquired pellicle on enamel.
The objective of this randomized, crossover and in situ study was to evaluate the anti-erosion potential of fluoride solutions associated with aminomethacrylate biopolymer on enamel. Twelve volunteers installed an intraoral device containing bovine enamel specimens. After 5 min, they performed the mouthwash (1 min) with one of the tested solutions: Ultrapure water (C); Fluorine (F, 225ppm F-); Stannous Chloride (S, 800ppm Sn+2); Aminomethacrylate (AMC, 2%); FS; AMC+F; AMC+FS and remained for 30 min with the device to allow maturation of the acquired pellicle. The specimens were then challenged with 0.03% hydrochloric acid, pH 2.3, 3 min extra orally. These steps were repeated 5 times. Each solution was tested in a different phase with the same volunteers, with a 2-day washout interval. The specimens were subjected to Knoop surface microhardness analysis before and after cycling, to calculate the percentage of microhardness reduction (%KHNred). Additionally, the concentration of fluorine soluble in KOH (µg/cm²) on the surface of the specimens was determined. Data were analyzed with RM-ANOVA and Tukey (5%). The mean %KHNred values were: C (-37.7 ± 4.6)A, S (-37.8 ± 4.9)A, AMC (-26.8 ± 2.5)B, F (- 31.0 ± 3.4)B, FS (-30.3 ± 5.0)B, AMC+F (-21.0 ± 4.9)C, AMC+FS (-19.3 ± 4.1) )W. The KOH-soluble fluorine concentration results were: C = S = AMC < F < AMC+F ≤ AMC+FS ≤ FS. It was concluded that the AMC biopolymer increased the anti-erosion effect of fluorine associated or not with tin in the presence of the acquired pellicle on enamel.
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Palavras-chave
Erosão dentária, Esmalte dentário, Fluoreto de sódio, Polímeros, Tooth rrosion, Dental enamel, Polymers, Sodium fluoride