Hepatic effects of the clomazone herbicide in both its free form and associated with chitosan-alginate nanoparticles in bullfrog tadpoles

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dc.contributor.authorOliveira, Cristiane Ronchi de [UNESP]
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorRizzi, Gisele Miglioranza
dc.contributor.authorSalla, Raquel Fernanda
dc.contributor.authorAbdalla, Fábio Camargo
dc.contributor.authorCosta, Monica Jones
dc.contributor.authorSilva-Zacarin, Elaine Cristina Mathias
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:34Z
dc.date.available2018-12-11T17:01:34Z
dc.date.issued2016-04-01
dc.description.abstractThe use of agrochemicals in agriculture is intense and most of them could be carried out to aquatic environment. Nevertheless, there are only few studies that assess the effects of these xenobiotics on amphibians. Clomazone is an herbicide widely used in rice fields, where amphibian species live. Thus, those species may be threatened by non-target exposure. However, nanoparticles are being developed to be used as a carrier system for the agrochemicals. Such nanoparticles release the herbicide in a modified way, and are considered to be more efficient and less harmful to the environment. The aim of this study was to comparatively evaluate the effect of clomazone in its free form and associated with nanoparticles, in the liver of bullfrog tadpoles (Lithobates catesbeianus) when submitted to acute exposure for 96 h. According to semi-quantitative analysis, there was an increase in the frequency of melanomacrophage centres, in the accumulation of eosinophils and in lipidosis in the liver of experimental groups exposed to clomazone - in its free form and associated with nanoparticles - in comparison with the control group, and the nanotoxicity of chitosan-alginate nanoparticles. The increase of melanomacrophage centres in all exposed groups was significant (P < 0.0001) in comparison to control group. Therefore, the results of this research have shown that exposure to sublethal doses of the herbicide and nanoparticles triggered hepatic responses. Moreover, these results provided important data about the effect of the clomazone herbicide and organic nanoparticles, which act as carriers of agrochemicals, on the bullfrog tadpole liver.en
dc.description.affiliationLaboratory of Structural and Functional Biology (LABEF) Universidade Federal de São Carlos (UFSCar), Campus Sorocaba. Rodovia João Leme dos Santos, Km 110 - SP-264
dc.description.affiliationLaboratory of Conservation Physiology (LAFISC) Universidade Federal de São Carlos (UFSCar), Campus Sorocaba. Rodovia João Leme dos Santos, Km 110 - SP-264
dc.description.affiliationDepartament of Environmental Engineering Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Campus Sorocaba. Avenida três de março, n. 511
dc.description.affiliationUnespDepartament of Environmental Engineering Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Campus Sorocaba. Avenida três de março, n. 511
dc.format.extent304-313
dc.identifierhttp://dx.doi.org/10.1016/j.chemosphere.2016.01.076
dc.identifier.citationChemosphere, v. 149, p. 304-313.
dc.identifier.doi10.1016/j.chemosphere.2016.01.076
dc.identifier.file2-s2.0-84960098653.pdf
dc.identifier.issn1879-1298
dc.identifier.issn0045-6535
dc.identifier.scopus2-s2.0-84960098653
dc.identifier.urihttp://hdl.handle.net/11449/172643
dc.language.isoeng
dc.relation.ispartofChemosphere
dc.relation.ispartofsjr1,435
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEcotoxicology
dc.subjectFrog
dc.subjectLipidosis
dc.subjectLiver
dc.subjectMelanomacrophage centres
dc.subjectNanotoxicity
dc.titleHepatic effects of the clomazone herbicide in both its free form and associated with chitosan-alginate nanoparticles in bullfrog tadpolesen
dc.typeArtigo
unesp.author.orcid0000-0001-9424-947X[6]

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Artigos - Engenharia Ambiental - Sorocaba