Upregulation of Soluble HLA-G5 and HLA-G6 Isoforms in the Milder Histopathological Stages of Helicobacter pylori Infection: A Role for Subverting Immune Responses?

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dc.contributor.authorOliveira Souza, D. M. B.
dc.contributor.authorGenre, J.
dc.contributor.authorAlves Silva, T. G. [UNESP]
dc.contributor.authorSoares, C. P. [UNESP]
dc.contributor.authorBorges Ferreira Rocha, K.
dc.contributor.authorNunes Oliveira, C.
dc.contributor.authorNunes Jatoba, C. A.
dc.contributor.authorMarco de Leon Andrade, J.
dc.contributor.authorMoreau, P.
dc.contributor.authorCunha Medeiros, A. da
dc.contributor.authorDonadi, E. A.
dc.contributor.authorOliveira Crispim, J. C. de
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionHop St Louis 1
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-11-26T15:28:23Z
dc.date.available2018-11-26T15:28:23Z
dc.date.issued2016-01-01
dc.description.abstractThe subversion mechanisms employed by Helicobacter pylori (H.pylori) to escape from immune surveillance and to establish persistent infection are poorly understood. Growing evidence indicates that expression of HLA-G, a non-classical major histocompatibility complex molecule, negatively regulates immune responses in pathological conditions, including infectious diseases. In this context, we aimed to evaluate HLA-G expression in the gastric microenvironment of individuals harbouring H.pylori and to correlate it with histological variables. Fifty-four gastric specimens from patients harbouring H.pylori infection were evaluated by immunohistochemistry using anti-HLA-G monoclonal antibody. As a result, HLA-G expression was detected in 43 of 54 specimens harbouring H.pylori. The presence of HLA-G was significantly associated with milder colonization by H.pylori (P<0.02), milder inflammatory activity (P<0.02) and bacterium histological location in the gastric antrum. This study is the first to explore HLA-G expression in the context of bacterial infection. Whether the biological role of HLA-G during H.pylori infection is beneficial or hazardous for patients remains to be defined.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Fac Farm, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, BR-59012570 Natal, RN, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Fac Farm, Ctr Ciencias Saude, Programa Posgrad Ciencias Saude, BR-59012570 Natal, RN, Brazil
dc.description.affiliationUniv Estadual Julio de Mesquita Filho, Fac Ciencias Farmaceut, Dept Anal Clin, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Ctr Ciencias Saude, Fac Med, Dept Patol, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniv Brasilia, Inst Ciencias Exatas, Dept Estat, Brasilia, DF, Brazil
dc.description.affiliationHop St Louis 1, Inst Malad Emergentes & Therapies Innovantes, Serv Rech Hematoimmunol, Commissariat Energie Atom & Energies Alternat, Paris, France
dc.description.affiliationUniv Paris Diderot, Sorbonne Paris Cite, Hop St Louis 1, UMR Inst Univ Hematol E5, Paris, France
dc.description.affiliationUniv Fed Rio Grande do Norte, Fac Med, Ctr Ciencias Saude, Dept Cirurgia, BR-59012570 Natal, RN, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Div Imunol Clin, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Julio de Mesquita Filho, Fac Ciencias Farmaceut, Dept Anal Clin, Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUFRN Pharmaceutical Sciences Post-graduation Program
dc.format.extent38-43
dc.identifierhttp://dx.doi.org/10.1111/sji.12385
dc.identifier.citationScandinavian Journal Of Immunology. Hoboken: Wiley-blackwell, v. 83, n. 1, p. 38-43, 2016.
dc.identifier.doi10.1111/sji.12385
dc.identifier.issn0300-9475
dc.identifier.urihttp://hdl.handle.net/11449/158630
dc.identifier.wosWOS:000366927600006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofScandinavian Journal Of Immunology
dc.relation.ispartofsjr0,891
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleUpregulation of Soluble HLA-G5 and HLA-G6 Isoforms in the Milder Histopathological Stages of Helicobacter pylori Infection: A Role for Subverting Immune Responses?en
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell

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