Adult partner preference and sexual behavior of male rats exposed prenatally to betamethasone

Página do item simplificado
dc.contributor.authorPiffer, Renata C.
dc.contributor.authorGarcia, Patricia C.
dc.contributor.authorPereira, Oduvaldo C. M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:21Z
dc.date.available2014-05-20T13:33:21Z
dc.date.issued2009-08-04
dc.description.abstractThe aim of this Study was to investigate long-term effects of prenatal betamethasone exposure oil sexual partner preference, testosterone level, and sexual behavior. Pregnant rats received 0.1 mg/kg of betamethasone or saline on the 12th, 13th, 18th, and 19th days of pregnancy. Parameters in male offspring were evaluated at 90 days of age. Male rats from the betamethasone group did not show any difference in sexual partner preference as expressed by the total number of visits to the female or male zone. However, these males spent significantly less total time and shorter duration per visit in the female zone than their controls. Therefore, prenatal exposure to betamethasone led to a significantly lower sexual female partner preference score compared to the control group. These animals also presented diminished testosterone levels in adulthood. Prenatal exposure to betamethasone induced a delay in the latency to first ejaculation. as well as a decrease in the numbers of postejaculatory intromissions, total intromissions and total ejaculations. Although 80% of the betamethasone-treated animals exhibited male Sexual behavior, when they were castrated and pretreated with estrogen, 50% of them showed lordosis and accepted mounts of another sexually experienced male. These results suggest that the prenatal treatment with betamethasone, by increasing maternal corticosteroid level, may have diminished testosterone peak in male pups, a peak crucial to brain sexual differentiation. As a consequence, the prenatal betamethasone treatment reduced the testosterone level in adulthood and altered partner preference and Sexual behavior. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationSao Paula State Univ, UNESP, Botucatu Med Sch, Dept Clin Med, BR-18618000 São Paulo, Brazil
dc.description.affiliationSao Paula State Univ, UNESP, Inst Biosci, Dept Pharmacol, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSao Paula State Univ, UNESP, Botucatu Med Sch, Dept Clin Med, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSao Paula State Univ, UNESP, Inst Biosci, Dept Pharmacol, BR-18618000 São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 142388/2004-1
dc.description.sponsorshipIdFAPESP: 06/57038-6
dc.format.extent163-167
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2009.05.003
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 98, n. 1-2, p. 163-167, 2009.
dc.identifier.doi10.1016/j.physbeh.2009.05.003
dc.identifier.issn0031-9384
dc.identifier.urihttp://hdl.handle.net/11449/11414
dc.identifier.wosWOS:000268369700023
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPhysiology & Behavior
dc.relation.ispartofjcr2.517
dc.relation.ispartofsjr1,088
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPrenatal betamethasoneen
dc.subjectCorticotherapyen
dc.subjectBrain sexual differentiationen
dc.subjectSexual partner preferenceen
dc.subjectSexual behavioren
dc.subjectTestosteroneen
dc.subjectMale raten
dc.titleAdult partner preference and sexual behavior of male rats exposed prenatally to betamethasoneen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Clínica Médica - FMB