Participação do Estado Contrátil e do Relaxamento Miocárdico na Disfunção Ventricular durante a Transição Hipertrofia-Falência Cardíaca

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dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorRobinson, Kathleen G.
dc.contributor.authorConrad, Chester H.
dc.contributor.authorSquire, Robin
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.authorBing, Oscar H. L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:18Z
dc.date.available2014-05-27T11:18:18Z
dc.date.issued1997-12-01
dc.description.abstractPurpose - To investigate the participation of contractile state and relaxation in cardiac muscle dysfunction during the transition from stable hypertrophy to cardiac decompensation in aging spontaneously hypertensive rats (SHR). Methods - isolated left ventricular papillary muscle function was studied in SHR with heart failure (SHR-F), in age-matched SHR without evidence of heart failure (SHR-NF), and in nonhypertensive controls Wistar-Kyoto rats (WKY). Muscles were analised in isometric and isotonic contractions in Krebs-Henseleit solution with calcium concentration of 1.25mM at 28°C. Results - Papillary muscles from SHR-F and SHR-NF demonstrated decreased active tension development and shortening velocity relative to normotensive WKY (p<0.05). SHR-F and SHR-NF did not differ. Compared with SHR-NF and WKY, muscle passive stiffness was increased in the failing SHR (p<0.05 versus WKY and SHR-NF). This parameter did not differ between SHR-NF and WKY (p> 0.05). Conclusion - These data suggest that the progression from stable hypertrophy to heart failure is associated with changes in the passive stiffness and is not related to depression of myocardial contractile function.en
dc.description.affiliationFaculdade de Medicina de Botucatu Depto. de Clin. Médica, Rubião Júnior, S/N, 18618-000 - Botucatu, SP
dc.description.affiliationUnespFaculdade de Medicina de Botucatu Depto. de Clin. Médica, Rubião Júnior, S/N, 18618-000 - Botucatu, SP
dc.format.extent381-384
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X1997001200003
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 69, n. 6, p. 381-384, 1997.
dc.identifier.doi10.1590/S0066-782X1997001200003
dc.identifier.file2-s2.0-0031321453.pdf
dc.identifier.issn0066-782X
dc.identifier.lattes9418970103564137
dc.identifier.lattes4463138671998432
dc.identifier.scieloS0066-782X1997001200003
dc.identifier.scopus2-s2.0-0031321453
dc.identifier.urihttp://hdl.handle.net/11449/65289
dc.language.isopor
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHeart failure
dc.subjectHypertrophy
dc.subjectMyocardial function
dc.subjectanimal
dc.subjectcomparative study
dc.subjectforward heart failure
dc.subjectheart contraction
dc.subjectheart left ventricle function
dc.subjectheart left ventricle hypertrophy
dc.subjectheart right ventricle hypertrophy
dc.subjecthypertension
dc.subjectmale
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectrat
dc.subjectWistar Kyoto rat
dc.subjectAnimals
dc.subjectCardiac Output, Low
dc.subjectHypertension
dc.subjectHypertrophy, Left Ventricular
dc.subjectHypertrophy, Right Ventricular
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectRats
dc.subjectRats, Inbred WKY
dc.subjectVentricular Dysfunction, Left
dc.titleParticipação do Estado Contrátil e do Relaxamento Miocárdico na Disfunção Ventricular durante a Transição Hipertrofia-Falência Cardíacapt
dc.title.alternativeMyocardial Function during the Transition from Compensated Left Ventricular Hypertrophy to Failureen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/abc/paboutj.htm#03
unesp.author.lattes4463138671998432
unesp.author.lattes9418970103564137[1]
unesp.author.orcid0000-0002-4402-6523[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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