Biological differences between reflux stimulated proliferative stomal lesions and N-methyl-N '-nitro-N-nitrosoguanidine induced carcinomas in Wistar rats.

Página do item simplificado
dc.contributor.authorRodrigues, MAM
dc.contributor.authorKobayasi, Shoiti [UNESP]
dc.contributor.authorNaresse, Luiz Eduardo [UNESP]
dc.contributor.authorLeite, CVD
dc.contributor.authorNakanishi, H.
dc.contributor.authorImai, T.
dc.contributor.authorTatematsu, M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAichi Canc Ctr
dc.date.accessioned2014-05-20T13:37:00Z
dc.date.available2014-05-20T13:37:00Z
dc.date.issued1999-10-18
dc.description.abstractThe morphology and evolution of epithelial lesions that developed at a gastrojejunal stoma due to reflux of duodenal contents were compared with MNNG-induced carcinomas in the pyloric mucosa of rats in a long term experiment. Random bred male Wistar rats were given MNNG in drinking water (100 mg/l) for 12 weeks and then one group was submitted to a gastrojejunal anastomosis at the greater curvature in the oxyntic mucosa, Untreated rats underwent either gastrojejunostomy or gastrotomy. The animals were killed at the 24th and 66th weeks of the experiment. The lesions obtained in the pyloric mucosa and in the mucosa of the gastrojejunal stoma were analyzed histologically using hematoxylin and eosin staining and immunohistochemistry for pepsinogen isoenzyme 1. Duodenal reflux induced proliferative lesions at the gastrojejunal junction that increased in incidence and size with time. Histologically they consisted of benign epithelial proliferation of gastric type. No evidence of malignant transformation within the gastric components of the proliferative lesions at the gastrojejunal stoma was observed even at the 66th week, Adenocarcinomas induced by MNNG in the pyloric mucosa increased in size during the experiment and were morphologically and histochemically distinct from the proliferative lesions at the gastrojejunal junction. In conclusion, proliferative lesions at the gastrojejunal stoma stimulated by duodenal reflux are biologically distinct from adenocarcinomas induced by MNNG in the pyloric mucosa. They do not seem to be precursor lesions of gastric carcinogenesis, as they do not undergo malignant transformation even after long-term, up to 66 weeks, follow-up. (C) 1999 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo State, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo State, UNESP, Botucatu Med Sch, Dept Surg, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationAichi Canc Ctr, Res Inst, Pathol Lab, Chikusa Ku, Nagoya, Aichi 464, Japan
dc.description.affiliationUnespUniv São Paulo State, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State, UNESP, Botucatu Med Sch, Dept Surg, BR-18618000 Botucatu, SP, Brazil
dc.format.extent85-91
dc.identifierhttp://dx.doi.org/10.1016/S0304-3835(99)00235-9
dc.identifier.citationCancer Letters. Clare: Elsevier Sci Ireland Ltd, v. 145, n. 1-2, p. 85-91, 1999.
dc.identifier.doi10.1016/S0304-3835(99)00235-9
dc.identifier.issn0304-3835
dc.identifier.lattes3191019476459702
dc.identifier.lattes3769255547738283
dc.identifier.urihttp://hdl.handle.net/11449/12763
dc.identifier.wosWOS:000082705700012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Letters
dc.relation.ispartofjcr6.491
dc.relation.ispartofsjr2,350
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectstomal lesionspt
dc.subjectduodenal refluxpt
dc.subjectmorphology of tumorspt
dc.subjectN-methyl-N '-nitro-N-nitrosoguanidinept
dc.subjectrat gastric carcinogenesispt
dc.titleBiological differences between reflux stimulated proliferative stomal lesions and N-methyl-N '-nitro-N-nitrosoguanidine induced carcinomas in Wistar rats.en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3191019476459702
unesp.author.lattes3769255547738283
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Patologia - FMB