A disposaable electrochemical sensor for the rapid determination of levodopa

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dc.contributor.authorBergamini, M. F.
dc.contributor.authorSantos, A. L.
dc.contributor.authorStradiotto, Nelson Ramos [UNESP]
dc.contributor.authorZanoni, Maria Valnice Boldrin [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:17Z
dc.date.available2014-05-20T15:27:17Z
dc.date.issued2005-09-01
dc.description.abstractLevodopa (L-dopa), the biological precursor of catecholamines, is the most widely prescribed drug in the treatment of Parkinson's disease. The present work presents a proposal for the application of a gold screen-printed electrode an electrochemical sensor for monitoring L-dopa in stationary solution and a flow system. Using the electrooxidation of L-dopa at +0.63 V in acetate buffer pH 3.0 on a gold screen-printed electrode it is possible to obtain a linear calibration curve from 9.9 x 10(-5) to 1.2 x 10(-3) mol L-1 and a detection limit of 6.8 x 10(-5) mol L-1. Under amperometric conditions (E-app = 0.8 V; flow rate = 14.1 ml, min(-1); pH 3.0), an analytical calibration graph for L-dopa was obtained from 1.0 x 10(-6) mol L-1 6.6 x 10(-4) mol L-1 with a detection limit of 9.9 x 10(-7) mol L-1. The method was successfully applied to the determination of L-dopa in commercial dosage forms without any pre-treatment. (c) 2005 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Analit, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Analit, BR-14801970 Araraquara, SP, Brazil
dc.format.extent54-59
dc.identifierhttp://dx.doi.org/10.1016/j.jpba.2005.03.014
dc.identifier.citationJournal of Pharmaceutical and Biomedical Analysis. Oxford: Pergamon-Elsevier B.V., v. 39, n. 1-2, p. 54-59, 2005.
dc.identifier.doi10.1016/j.jpba.2005.03.014
dc.identifier.issn0731-7085
dc.identifier.lattes0072173018005712
dc.identifier.orcid0000-0002-2296-1393
dc.identifier.urihttp://hdl.handle.net/11449/37297
dc.identifier.wosWOS:000232209600009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.relation.ispartofjcr2.831
dc.relation.ispartofsjr0,919
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectL-dopapt
dc.subjectscreen-printed gold electrodept
dc.subjectamperometric determinationpt
dc.subjectflow systempt
dc.titleA disposaable electrochemical sensor for the rapid determination of levodopaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0072173018005712
unesp.author.orcid0000-0002-2296-1393[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Analítica - IQ