Biologic and genetics aspects of chagas disease at endemic areas

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dc.contributor.authorBellini, Marilanda Ferreira [UNESP]
dc.contributor.authorSilistino-Souza, Rosana [UNESP]
dc.contributor.authorVarella-Garcia, Marileila
dc.contributor.authorOliveira, Maria Tercília Vilela de Azeredo [UNESP]
dc.contributor.authorSilva, Ana Elizabete [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Colorado Health Sciences Center
dc.contributor.institutionResearch Center 1 South Tower
dc.date.accessioned2014-05-27T11:26:27Z
dc.date.available2014-05-27T11:26:27Z
dc.date.issued2012-04-19
dc.description.abstractThe etiologic agent of Chagas Disease is the Trypanosoma cruzi, transmitted through blood-sucking insect vectors of the Triatominae subfamily, representing one of the most serious public health concerns in Latin America. There are geographic variations in the prevalence of clinical forms and morbidity of Chagas disease, likely due to genetic variation of the T. cruzi and the host genetic and environmental features. Increasing evidence has supported that inflammatory cytokines and chemokines are responsible for the generation of the inflammatory infiltrate and tissue damage. Moreover, genetic polymorphisms, protein expression levels, and genomic imbalances are associated with disease progression. This paper discusses these key aspects. Large surveys were carried out in Brazil and served as baseline for definition of the control measures adopted. However, Chagas disease is still active, and aspects such as host-parasite interactions, genetic mechanisms of cellular interaction, genetic variability, and tropism need further investigations in the attempt to eradicate the disease. Copyright 2012 Marilanda Ferreira Bellini et al.en
dc.description.affiliationDepartment of Especial Education UNESP São Paulo State University, 17525-900 Campus Marília, SP
dc.description.affiliationDepartment of Biology UNESP São Paulo State University, 15054-000 Campus São José do Rio Preto, SP
dc.description.affiliationMedicine/Medical Oncology University of Colorado Health Sciences Center, Aurora, CO 80045-0511
dc.description.affiliationUniversity of Colorado School of Medicine Anschutz Medical Campus Research Center 1 South Tower, Aurora, CO 80045-0511
dc.description.affiliationUnespDepartment of Especial Education UNESP São Paulo State University, 17525-900 Campus Marília, SP
dc.description.affiliationUnespDepartment of Biology UNESP São Paulo State University, 15054-000 Campus São José do Rio Preto, SP
dc.identifierhttp://dx.doi.org/10.1155/2012/357948
dc.identifier.citationJournal of Tropical Medicine.
dc.identifier.doi10.1155/2012/357948
dc.identifier.file2-s2.0-84859765861.pdf
dc.identifier.issn1687-9686
dc.identifier.issn1687-9694
dc.identifier.lattes6045437265946340
dc.identifier.scopus2-s2.0-84859765861
dc.identifier.urihttp://hdl.handle.net/11449/73289
dc.language.isoeng
dc.relation.ispartofJournal of Tropical Medicine
dc.relation.ispartofsjr0,508
dc.relation.ispartofsjr0,508
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectinsecticide
dc.subjectlymphotoxin
dc.subjectmolecular marker
dc.subjectorganophosphate insecticide
dc.subjecttransforming growth factor beta1
dc.subjectapoptosis
dc.subjectBrazil
dc.subjectcardiomyopathy
dc.subjectChagas disease
dc.subjectcoronary artery disease
dc.subjectcytokine production
dc.subjectdigestive system
dc.subjectdisease association
dc.subjectdisease carrier
dc.subjectdisease model
dc.subjectdisease transmission
dc.subjectenzyme linked immunosorbent assay
dc.subjectesophageal squamous cell carcinoma
dc.subjectextracellular matrix
dc.subjectgenetic polymorphism
dc.subjecthealth survey
dc.subjectheart disease
dc.subjectheart infarction
dc.subjecthost cell
dc.subjecthuman
dc.subjectimmune response
dc.subjectinflammation
dc.subjectlife cycle stage
dc.subjectlymphocyte proliferation
dc.subjectmegacolon
dc.subjectmegaesophagus
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectreview
dc.subjectsingle nucleotide polymorphism
dc.subjectT lymphocyte
dc.subjectTh1 cell
dc.subjectTrypanosoma cruzi
dc.subjecttrypomastigote
dc.subjectvector control
dc.titleBiologic and genetics aspects of chagas disease at endemic areasen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/aaa/guidelines/
unesp.advisor.lattes6045437265946340
unesp.author.lattes2503906319038306[5]
unesp.author.orcid0000-0003-1491-8878[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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