Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate

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dc.contributor.authorSarobo, Carolina [UNESP]
dc.contributor.authorLacorte, Livia M. [UNESP]
dc.contributor.authorMartins, Marcela [UNESP]
dc.contributor.authorRinaldi, Jaqueline C. [UNESP]
dc.contributor.authorMoroz, Andrei [UNESP]
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.authorDelella, Flávia Karina [UNESP]
dc.contributor.authorFelisbino, Sergio L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:52:06Z
dc.date.available2014-05-20T13:52:06Z
dc.date.issued2012-12-01
dc.description.abstractCoffee intake has been associated with a low risk of developing cancer, including prostate cancer, which is one of the most commonly diagnosed cancer in men. However, few studies have evaluated the chronic effects of caffeine, which is the most abundant methylxanthine in coffee, on prostate morphology and physiology. In the present study, we investigated the effects of chronic, low-dose caffeine intake on rat prostate morphology from puberty to adulthood. Five-week-old male Wistar rats were randomized into two experimental groups: caffeine-treated (20 ppm in drinking water, n = 12) and control (n = 12). The ventral and dorsolateral prostates were dissected, weighted and submitted to morphological, morphometrical and immunohistochemical analysis of cellular proliferation, apoptosis and androgen receptor (AR) tissue expression. The testosterone (T) and dihydrotestosterone (DHT) concentrations were measured in the plasma. Our results show that caffeine intake increased the concentrations of T and DHT, organ weight, epithelial cell proliferation and AR tissue expression in the ventral prostatic lobe. All the ventral prostates from the caffeine-treated animals presented various degrees of epithelial and stromal hyperplasia. Our results suggest that chronic caffeine intake from puberty increases androgenic signalling and cell proliferation in the rat prostate gland and can be related to the development of benign prostatic hyperplasia.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Morfol, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Morfol, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 09/52747-7
dc.description.sponsorshipIdFAPESP: 09/50850-5
dc.format.extent429-437
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2613.2012.00843.x/abstract
dc.identifier.citationInternational Journal of Experimental Pathology. Hoboken: Wiley-blackwell, v. 93, n. 6, p. 429-437, 2012.
dc.identifier.doi10.1111/j.1365-2613.2012.00843.x
dc.identifier.issn0959-9673
dc.identifier.urihttp://hdl.handle.net/11449/18617
dc.identifier.wosWOS:000310875300006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.relation.ispartofjcr1.938
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectandrogen receptoren
dc.subjectapoptosisen
dc.subjectcaffeineen
dc.subjectcell proliferationen
dc.subjecthyperplasiaen
dc.subjectprostateen
dc.titleChronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostateen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes6926124203948011[5]
unesp.author.orcid0000-0002-6682-2934[6]
unesp.author.orcid0000-0002-4498-9784[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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