Inflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exercise

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dc.contributor.authorCoelho Junior, Helio Jose
dc.contributor.authorGambassi, Bruno Bavaresco
dc.contributor.authorDiniz, Tiego Aparecido [UNESP]
dc.contributor.authorCruz Fernandes, Isabela Maia da [UNESP]
dc.contributor.authorCaperuto, Erico Chagas
dc.contributor.authorUchida, Marco Carlos
dc.contributor.authorLira, Fabio Santos [UNESP]
dc.contributor.authorRodrigues, Bruno
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSao Judas Tadeu Univ USJT
dc.date.accessioned2018-11-26T17:04:34Z
dc.date.available2018-11-26T17:04:34Z
dc.date.issued2016-01-01
dc.description.abstractInflammatory markers are increased systematically and locally (e.g., skeletal muscle) in stroke patients. Besides being associated with cardiovascular risk factors, proinflammatory cytokines seem to play a key role in muscle atrophy by regulating the pathways involved in this condition. As such, they may cause severe decrease in muscle strength and power, as well as impairment in cardiorespiratory fitness. On the other hand, physical exercise (PE) has been widely suggested as a powerful tool for treating stroke patients, since PE is able to regenerate, even if partially, physical and cognitive functions. However, the mechanisms underlying the beneficial effects of physical exercise in poststroke patients remain poorly understood. Thus, in this study we analyze the candidate mechanisms associated with muscle atrophy in stroke patients, as well as the modulatory effect of inflammation in this condition. Later, we suggest the two strongest anti-inflammatory candidate mechanisms, myokines and the cholinergic anti-inflammatory pathway, which may be activated by physical exercise and may contribute to a decrease in proinflammatory markers of poststroke patients.en
dc.description.affiliationUniv Campinas UNICAMP, Fac Phys Educ, BR-13083851 Campinas, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationSao Judas Tadeu Univ USJT, Human Movement Lab, BR-03166000 Sao Paulo, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent19
dc.identifierhttp://dx.doi.org/10.1155/2016/3957958
dc.identifier.citationMediators Of Inflammation. London: Hindawi Ltd, 19 p., 2016.
dc.identifier.doi10.1155/2016/3957958
dc.identifier.fileWOS000383105300001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/11449/161894
dc.identifier.wosWOS:000383105300001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofMediators Of Inflammation
dc.relation.ispartofsjr1,370
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleInflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exerciseen
dc.typeResenha
dcterms.rightsHolderHindawi Ltd
unesp.author.orcid0000-0003-3852-0602[2]
unesp.author.orcid0000-0003-4246-4703[8]

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