Alternate current biosusceptometry for the assessment of gastric motility after proximal gastrectomy in rats: a feasibility study

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dc.contributor.authorCalabresi, M. F. F. [UNESP]
dc.contributor.authorQuini, C. C. [UNESP]
dc.contributor.authorMatos, J. F. [UNESP]
dc.contributor.authorMoretto, G. M. [UNESP]
dc.contributor.authorAmerico, M. F.
dc.contributor.authorGraça, J. R. V.
dc.contributor.authorSantos, A. A.
dc.contributor.authorOliveira, R. B.
dc.contributor.authorPina, D. R. [UNESP]
dc.contributor.authorMiranda, J. R. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-12-07T15:32:49Z
dc.date.available2015-12-07T15:32:49Z
dc.date.issued2015
dc.description.abstractThis study proposes an experimental model to assess the consequences of gastric surgeries on gastric motility. We investigated the effects of proximal gastrectomy (PG) using a non-invasive technique (alternate current biosusceptometry [ACB]) on gastric contractility (GC), gastric emptying (GE), and orocecal transit (OCT) after the ingestion of liquids and solids in rats. Twenty-four male rats were subjected to gastric motility assessment before and after the PG procedure. The GE and OCT results are expressed as the mean time of gastric emptying (MGET) and cecum arrival (MCAT). The GC recordings are presented as the frequency and amplitude of contractions. Mean time of gastric emptying after solid meals were significantly different (p < 0.001) between control and PG (113 ± 5 to 99 ± 6 min). Mean time of cecum arrival ranged from 265 ± 9 to 223 ± 11 min (p < 0.001) and 164 ± 9 to 136 ± 17 min (p < 0.050) for solid and liquid meals, respectively. The assessment of GC showed that surgery decreased the phasic frequency (4.4 ± 0.4 to 3.0 ± 1.1 cpm, p < 0.050) and increased the amplitude of contractions (3.6 ± 2.7 to 7.2 ± 3.0 V/s, p < 0.050). No significant difference was found in tonic frequency. The ACB system was able to assess GE, OCT, and GC in gastrectomized rats. Overall, PG accelerated GE and gastrointestinal transit, likely due to the increase in both intragastric pressure and amplitude contraction. Our data presented an efficient model to investigate functional consequences from gastric surgeries that will allow further studies involving different procedures.en
dc.description.affiliationDepartamento de Física e Biofísica, Instituto de Biociências de Botucatu, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.description.affiliationInstituto de Ciências Biológicas e da Saúde, UFMT-Universidade Federal de Mato Grosso, Barra do Garças, Mato Grosso, Brazil.
dc.description.affiliationDepartamento de Fisiologia, Faculdade de Medicina de Sobral, UFC-Universidade Federal do Ceará, Sobral, Ceará, Brazil.
dc.description.affiliationDepartamento de Fisiologia e Farmacologia, Faculdade de Medicina, UFC-Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
dc.description.affiliationDepartamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, USP-Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
dc.description.affiliationDepartamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.description.affiliationUnespDepartamento de Física e Biofísica, Instituto de Biociências de Botucatu, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.description.affiliationUnespDepartamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1613-1620
dc.identifierhttp://dx.doi.org/10.1111/nmo.12660
dc.identifier.citationNeurogastroenterology And Motility : The Official Journal Of The European Gastrointestinal Motility Society, v. 27, n. 11, p. 1613-1620, 2015.
dc.identifier.doi10.1111/nmo.12660
dc.identifier.issn1365-2982
dc.identifier.pubmed26303680
dc.identifier.urihttp://hdl.handle.net/11449/131226
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofNeurogastroenterology And Motility : The Official Journal Of The European Gastrointestinal Motility Society
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAc biosusceptometryen
dc.subjectGastric contractilityen
dc.subjectGastric emptyingen
dc.subjectGastric motilityen
dc.subjectProximal gastrectomyen
dc.titleAlternate current biosusceptometry for the assessment of gastric motility after proximal gastrectomy in rats: a feasibility studyen
dc.typeArtigo
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0002-8306-8056[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Física e Biofísica - IBB
Artigos - Doenças Tropicais e Diagnósticos por Imagem - FMB