Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers

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dc.contributor.authorCaram, Laura Miranda de Oliveira [UNESP]
dc.contributor.authorFerrari, R. [UNESP]
dc.contributor.authorNogueira, D. L. [UNESP]
dc.contributor.authorOliveira, M. R.M. [UNESP]
dc.contributor.authorFrancisqueti, F. V. [UNESP]
dc.contributor.authorTanni, S. E. [UNESP]
dc.contributor.authorCorrêa, C. R. [UNESP]
dc.contributor.authorGodoy, I. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:13:30Z
dc.date.available2018-12-11T17:13:30Z
dc.date.issued2017-07-07
dc.description.abstractIntroduction: Oxidative stress and systemic inflammation are higher in smokers and patients with COPD; however, markers that may help differentiate between smokers and patients with COPD have not yet been identified. We hypothesized that tumor necrosis factor-alpha receptor (TNFR) and soluble form of the receptor for advanced glycation end products (sRAGE) can be indicators of COPD in asymptomatic patients. Patients and methods: We evaluated 32 smokers (smoking history >10 pack-years), 32 patients with mild/moderate COPD (smokers and ex-smokers), and 32 never smokers. Concentrations of C-reactive protein (CRP), interleukin (IL)-6, TNFR1 and TNFR2, advanced glycation end products (AGEs), and the sRAGE were measured in serum. Results: There were higher CRP and AGEs concentrations in smokers and in patients with COPD (P<0.001 and P=0.01, respectively) compared to controls, without statistical difference between smokers and patients with COPD. Concentrations of sRAGE, IL-6, and TNFR1 did not differ between study groups. TNFR2 was significantly higher in patients with COPD than in smokers (P=0.004) and controls (P=0.004), and the presence of COPD (P=0.02) and CRP (P=0.001) showed a positive association with TNFR2. Positive associations for smoking (P=0.04), CRP (P=0.03), and IL-6 (P=0.03) with AGEs were also found. The interaction variable (smoking × COPD) showed a positive association with IL-6. Conclusion: Our data suggest that TNFR2 may be a possible marker of COPD in asymptomatic smokers and ex-smokers. Although smokers and patients with early COPD presented other increased systemic inflammation markers (eg, CRP) and oxidative stress (measured by AGEs), they did not differentiate smokers from COPD.en
dc.description.affiliationDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista, Botucatu Campus
dc.description.affiliationDepartment of Pathology Botucatu Medical School UNESP – Univ Estadual Paulista, Botucatu Campus
dc.description.affiliationUnespDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista, Botucatu Campus
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School UNESP – Univ Estadual Paulista, Botucatu Campus
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/22321-0
dc.format.extent2015-2021
dc.identifierhttp://dx.doi.org/10.2147/COPD.S138558
dc.identifier.citationInternational Journal of COPD, v. 12, p. 2015-2021.
dc.identifier.doi10.2147/COPD.S138558
dc.identifier.issn1178-2005
dc.identifier.issn1176-9106
dc.identifier.scopus2-s2.0-85024882356
dc.identifier.urihttp://hdl.handle.net/11449/174927
dc.language.isoeng
dc.relation.ispartofInternational Journal of COPD
dc.relation.ispartofsjr1,395
dc.relation.ispartofsjr1,395
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectChronic obstructive pulmonary disease
dc.subjectInflammation mediators
dc.subjectOxidative stress
dc.subjectSmoking
dc.titleTumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokersen
dc.typeArtigo

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