Ethopharmacological evaluation of the rat exposure test: A prey-predator interaction test

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dc.contributor.authorCampos, Kelciane Ferreira Caetano [UNESP]
dc.contributor.authorAmaral, Vanessa Cristiane Santana [UNESP]
dc.contributor.authorRico, Javier Leonardo [UNESP]
dc.contributor.authorMiguel, Tarciso Tadeu [UNESP]
dc.contributor.authorNunes-de-Souza, Ricardo Luiz [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Goiás (UEG)
dc.contributor.institutionFundación Universitaria Konrad Lorenz
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:28:33Z
dc.date.available2014-05-27T11:28:33Z
dc.date.issued2013-03-01
dc.description.abstractThe rat exposure test (RET) is a prey (mouse)-predator (rat) situation that activates brain defensive areas and elicits hormonal and defensive behavior in the mouse. Here, we investigated possible correlations between the spatiotemporal [time spent in protected (home chamber and tunnel) and unprotected (surface) compartments and frequency of entries into the three compartments] and ethological [e.g., duration of protected and unprotected stretched-attend postures (SAP), duration of contact with the rat's compartment] measures (Experiment 1). Secondly, we investigated the effects of systemic treatment with pro- or anti-aversive drugs on the behavior that emerged from the factor analysis (Experiment 2). The effects of chronic (21 days) imipramine and fluoxetine on defensive behavior were also investigated (Experiment 3). Exp. 1 revealed that the time in the protected compartment, protected SAP and rat contacts loaded on factor 1 (defensive behavior), while the total entries and unprotected SAP loaded on factor 2 (locomotor activity). Exp. 2 showed that alprazolam (but not diazepam) selectively changed the defensive factor. Caffeine produced a mild proaversive-like effect, whereas yohimbine only decreased locomotor activity (total entries). Fluoxetine (but not imipramine) produced a weak proaversive-like effect. 5-HT1A/5-HT2 receptor ligands did not change any behavioral measure. In Exp. 3, chronic fluoxetine (but not imipramine) attenuated the defensive behavior factor without changing locomotion. Given that the defensive factor was sensitive to drugs known to attenuate (alprazolam and chronic fluoxetine) and induce (caffeine) panic attack, we suggest the RET as a useful test to assess the effects of panicolytic and panicogenic drugs. © 2012 Elsevier B.V.en
dc.description.affiliationLaboratory of Pharmacology School of Pharmaceutical Sciences Universidade Estadual Paulista, UNESP, Araraquara, SP 14801-902
dc.description.affiliationJoint Graduate Program in Physiological Sciences UFSCar UNESP. Rod. Washington Luís, Km 235, São Carlos, SP 13565-905
dc.description.affiliationUnidade Universitária de Ciências Exatas e Tecnológicas UnUCET-UEG, Br 153 n.3105, CEP: 75132-903 Anápolis, GO
dc.description.affiliationLaboratory of Animal Behavior Fundación Universitaria Konrad Lorenz, Bogotá
dc.description.affiliationInstitute for Neuroscience and Behavior-IneC USP, Ribeirão Preto, SP 14040-901
dc.description.affiliationUnespLaboratory of Pharmacology School of Pharmaceutical Sciences Universidade Estadual Paulista, UNESP, Araraquara, SP 14801-902
dc.description.affiliationUnespJoint Graduate Program in Physiological Sciences UFSCar UNESP. Rod. Washington Luís, Km 235, São Carlos, SP 13565-905
dc.format.extent160-170
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2012.11.023
dc.identifier.citationBehavioural Brain Research, v. 240, n. 1, p. 160-170, 2013.
dc.identifier.doi10.1016/j.bbr.2012.11.023
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549
dc.identifier.scopus2-s2.0-84871387916
dc.identifier.urihttp://hdl.handle.net/11449/74652
dc.identifier.wosWOS:000319542600021
dc.language.isoeng
dc.relation.ispartofBehavioural Brain Research
dc.relation.ispartofjcr3.173
dc.relation.ispartofsjr1,413
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectFactor analysis
dc.subjectMice
dc.subjectPanicogenic drugs
dc.subjectPanicolytic drugs
dc.subjectPrey-predator interaction
dc.subjectRat exposure test
dc.subjectalprazolam
dc.subjectcaffeine
dc.subjectdiazepam
dc.subjectfluoxetine
dc.subjectimipramine
dc.subjectserotonin 1A receptor
dc.subjectserotonin 2 receptor
dc.subjectyohimbine
dc.subjectacute drug administration
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectattenuation
dc.subjectaversive behavior
dc.subjectbehavior change
dc.subjectbody posture
dc.subjectchronic drug administration
dc.subjectclimbing
dc.subjectcontrolled study
dc.subjectdefensive behavior
dc.subjectdose response
dc.subjectdrug dose comparison
dc.subjectdrug effect
dc.subjectdrug potency
dc.subjectexperimental test
dc.subjectgrooming
dc.subjectlocomotion
dc.subjectlong term exposure
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpanic
dc.subjectpredator avoidance
dc.subjectpredator prey interaction
dc.subjectpriority journal
dc.subjectrat
dc.subjectrat exposure test
dc.subjectvalidation process
dc.subjectAdrenergic alpha-2 Receptor Antagonists
dc.subjectAlprazolam
dc.subjectAnimals
dc.subjectAnti-Anxiety Agents
dc.subjectAntidepressive Agents
dc.subjectCaffeine
dc.subjectCentral Nervous System Stimulants
dc.subjectDiazepam
dc.subjectEscape Reaction
dc.subjectFactor Analysis, Statistical
dc.subjectFluoxetine
dc.subjectFood Chain
dc.subjectImipramine
dc.subjectMale
dc.subjectMotor Activity
dc.subjectPosture
dc.subjectPredatory Behavior
dc.subjectRats
dc.subjectRats, Long-Evans
dc.subjectTime Factors
dc.subjectYohimbine
dc.titleEthopharmacological evaluation of the rat exposure test: A prey-predator interaction testen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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