Serum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shock

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dc.contributor.authorCosta, Nara Aline [UNESP]
dc.contributor.authorGut, Ana Lúcia [UNESP]
dc.contributor.authorDorna, Mariana de Souza [UNESP]
dc.contributor.authorCoelho Pimentel, Jose Alexandre
dc.contributor.authorFranciscato Cozzolino, Silvia Maria
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorFernandes, Ana Angelica Henrique [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-12-03T13:10:31Z
dc.date.available2014-12-03T13:10:31Z
dc.date.issued2014-02-01
dc.description.abstractPurpose: The purpose of the study is to determine the influence of serum thiamine, glutathione peroxidase (GPx) activity, and serum protein carbonyl concentrations in hospital mortality in patients with septic shock.Materials and Methods: This prospective study included all patients with septic shock on admission or during intensive care unit (ICU) stay, older than 18 years, admitted to 1 of the 3 ICUs of the Botucatu Medical School, from January to August 2012. Demographic information, clinical evaluation, and blood sample were taken within the first 72 hours of the patient's admission or within 72 hours after septic shock diagnosis for serum thiamine, GPx activity, and protein carbonyl determination.Results: One hundred eight consecutive patients were evaluated. The mean age was 57.5 +/- 16.0 years, 63% were male, 54.6% died in the ICU, and 71.3% had thiamine deficiency. Thiamine was not associated with oxidative stress. Neither vitamin B1 levels nor the GPx activity was associated with outcomes in these patients. However, protein carbonyl concentration was associated with increased mortality.Conclusions: In patients with septic shock, oxidative stress was associated with mortality. On the other hand, thiamine was not associated with oxidative stress or mortality in these patients. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Internal Med, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Chem & Biochem, Inst Biol Sci, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Internal Med, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Chem & Biochem, Inst Biol Sci, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent249-252
dc.identifierhttp://dx.doi.org/10.1016/j.jcrc.2013.12.004
dc.identifier.citationJournal Of Critical Care. Philadelphia: W B Saunders Co-elsevier Inc, v. 29, n. 2, p. 249-252, 2014.
dc.identifier.doi10.1016/j.jcrc.2013.12.004
dc.identifier.issn0883-9441
dc.identifier.lattes5452093689066508
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.urihttp://hdl.handle.net/11449/112202
dc.identifier.wosWOS:000332409400013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Critical Care
dc.relation.ispartofjcr2.872
dc.relation.ispartofsjr1,184
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSeptic shocken
dc.subjectGlutathione peroxidaseen
dc.subjectMortalityen
dc.subjectThiamineen
dc.subjectProtein carbonylen
dc.titleSerum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shocken
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5016839015394547[7]
unesp.author.lattes5452093689066508[2]
unesp.author.lattes1213140801402647[6]
unesp.author.lattes7438704034471673
unesp.author.orcid0000-0002-5980-4367[10]
unesp.author.orcid0000-0003-4412-1990[9]
unesp.author.orcid0000-0002-5843-6232[6]
unesp.author.orcid0000-0001-5763-0829[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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