Does cotinine act upon reactive oxygen species and peroxidases?

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dc.contributor.authorVellosa, J. C R [UNESP]
dc.contributor.authorKhalil, N. M. [UNESP]
dc.contributor.authorFonseca, L. M. [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorOliveira, Olga Maria Mascarenhas de Faria [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:30Z
dc.date.available2014-05-27T11:22:30Z
dc.date.issued2007-06-19
dc.description.abstractNicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H 2O 2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.en
dc.description.affiliationUNESP - Sao Paulo State University Biochemistry and Technological Chemistry Department Chemistry Institute, Araraquara-SP
dc.description.affiliationUNESP - Sao Paulo State University Clinical Analysis Department School of Pharmaceutical Sciences, Araraquara-SP
dc.description.affiliationUnespUNESP - Sao Paulo State University Biochemistry and Technological Chemistry Department Chemistry Institute, Araraquara-SP
dc.description.affiliationUnespUNESP - Sao Paulo State University Clinical Analysis Department School of Pharmaceutical Sciences, Araraquara-SP
dc.format.extent65-70
dc.identifierhttp://dx.doi.org/10.1590/S0100-46702007000100009
dc.identifier.citationEcletica Quimica, v. 32, n. 1, p. 65-70, 2007.
dc.identifier.doi10.1590/S0100-46702007000100009
dc.identifier.file2-s2.0-34250335024.pdf
dc.identifier.issn0100-4670
dc.identifier.scieloS0100-46702007000100009
dc.identifier.scopus2-s2.0-34250335024
dc.identifier.urihttp://hdl.handle.net/11449/69721
dc.language.isoeng
dc.relation.ispartofEclética Química
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCotinine
dc.subjectMyeloperoxidase
dc.subjectNicotine
dc.subjectOxidative damage
dc.subjectROS
dc.titleDoes cotinine act upon reactive oxygen species and peroxidases?en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/eq/paboutj.htm
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Bioquímica e Tecnologia - IQ
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