HISTOMORPHOMETRICAL EVALUATION IN TESTIS AND EPIDIDYMIS OF RATS WITH PULMONARY EMPHYSEMA EXPERIMENTALLY INDUCED BY PROLONGED EXPOSURE TO CIGARETTE SMOKE

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dc.contributor.authorRibeiro, Amanda de Genova [UNESP]
dc.contributor.authorRibeiro-Paes, Joao Tadeu [UNESP]
dc.contributor.authorStessuk, Talita
dc.contributor.authorKozma, Rodrigo de Las Heras
dc.contributor.authorCherici Camargo, Isabel Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-11-26T16:48:24Z
dc.date.available2018-11-26T16:48:24Z
dc.date.issued2016-07-01
dc.description.abstractThe study evaluated the histomorphometrical aspects of testis and epididymis of adult rats with pulmonary emphysema experimentally induced by exposure to cigarette smoke for 30 weeks. Previous studies related to effects of the cigarette smoke on male reproductive tissue were performed in relatively shorter time periods and thus, it does not allow a direct correlation between smoke exposure and damage to reproductive structures like testis and epididymis. In order to evaluate the effect of cigarette smoke for long period on the testis and epididymis, twelve adult Wistar rats were divided into two groups: Control (CG; exposed to ambient air) and Smoking (SG; exposed to cigarette smoke). The weight of the testes, epididymides, seminal glands and prostate were not affected (p>0.05) by experimental treatment. In the SG, the testes presented cellular desquamation, significant decrease in the number of germ cells and Sertoli cell, and reduction (p<0.05) in area and diameter of seminiferous tubules. The exposure of animals to cigarette smoke did not promoted histological changes in the epididymis, but decreased significantly the ductular area and epithelial height in the caput and corpus regions. It was concluded that testis was more susceptible than the epididymis to the effects of cigarette smoke constituents in rats with pulmonary emphysema experimentally induced by prolonged cigarette-smoke exposure.en
dc.description.affiliationUniv Estadual Paulista UNESP, Grad Ciencias Biol, Assis, SP, Brazil
dc.description.affiliationUNESP, Dept Ciencias Biol, Assis, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Programa Posgrad Biotecnol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Ciencias Biol, Assis, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Grad Ciencias Biol, Assis, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Ciencias Biol, Assis, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Ciencias Biol, Assis, SP, Brazil
dc.format.extent1092-1102
dc.identifier.citationBioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 32, n. 4, p. 1092-1102, 2016.
dc.identifier.issn1981-3163
dc.identifier.urihttp://hdl.handle.net/11449/161727
dc.identifier.wosWOS:000379770400029
dc.language.isoeng
dc.publisherUniv Federal Uberlandia
dc.relation.ispartofBioscience Journal
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectTobacco
dc.subjectReproductive toxicology
dc.subjectPulmonary emphysema
dc.subjectComorbities
dc.titleHISTOMORPHOMETRICAL EVALUATION IN TESTIS AND EPIDIDYMIS OF RATS WITH PULMONARY EMPHYSEMA EXPERIMENTALLY INDUCED BY PROLONGED EXPOSURE TO CIGARETTE SMOKEen
dc.typeArtigo
dcterms.rightsHolderUniv Federal Uberlandia
unesp.author.orcid0000-0002-4254-209X[3]

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