Diazepam influences urinary bioindicator of occupational toluene exposure

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dc.contributor.authorSilveira, Alberto Thalison
dc.contributor.authorAlbuquerque, Ana Carolina Campos
dc.contributor.authorLepera, Jose Salvador [UNESP]
dc.contributor.authorMartins, Isarita
dc.contributor.institutionUniv Fed Alfenas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:15:26Z
dc.date.available2018-11-26T17:15:26Z
dc.date.issued2016-12-01
dc.description.abstractIn the present study, we investigated the influence of diazepam (DZP) on the excretion of TOL by examining their urinary metabolites, hippuric acid (HA) and ortho-cresol (o-C). Male Wistar rats were exposed to TOL (20 ppm) in a nose-only exposure chamber (6 h/day, 5 days/week for 6 weeks) with simultaneous administration of DZP (10 mg/kg/day). Urinary o-C levels were determined by GC MS, while HA, creatinine (CR), DZP and its metabolite, nordiazepam, were analysed by HPLC-DAD. The results of a Mann-Whitney U test showed that DZP influenced the urinary excretion of o-C (p < 0.05). This pioneering study revealed that there was an interaction between DZP and TOL, probably by the inhibition of the CYP isoforms (CYP2B6, CYP2C8, CYP2E1, and CYP1A2) involved in the oxidative metabolism of the solvent. ThiS is relevant information to be considered in the biomonitoring of occupational toluene exposure. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Alfenas, Unifal MG, Lab Toxicant & Drug Anal, Gabriel Monteiro da Silva St 700, BR-37130000 Alfenas, MG, Brazil
dc.description.affiliationUNESP, Fac Pharmaceut Sci Araraquara FCFAr, Lab Occupat Toxicol, Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Pharmaceut Sci Araraquara FCFAr, Lab Occupat Toxicol, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdFAPEMIG: APQ-01747-13
dc.format.extent191-196
dc.identifierhttp://dx.doi.org/10.1016/j.etap.2016.10.012
dc.identifier.citationEnvironmental Toxicology And Pharmacology. Amsterdam: Elsevier Science Bv, v. 48, p. 191-196, 2016.
dc.identifier.doi10.1016/j.etap.2016.10.012
dc.identifier.fileWOS000390517200024.pdf
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/11449/162274
dc.identifier.wosWOS:000390517200024
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEnvironmental Toxicology And Pharmacology
dc.relation.ispartofsjr0,813
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectToluene
dc.subjectDiazepam
dc.subjectOccupational exposure
dc.subjecto-Cresol
dc.subjectHippuric acid
dc.titleDiazepam influences urinary bioindicator of occupational toluene exposureen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR