Primary relapse site pattern in women with triple-negative breast cancer

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dc.contributor.authorBeca, Francisco
dc.contributor.authorSantos, Renata
dc.contributor.authorVieira, Daniella
dc.contributor.authorZeferino, Luiz
dc.contributor.authorDufloth, Rozany [UNESP]
dc.contributor.authorSchmitt, Fernando
dc.contributor.institutionUniv Porto
dc.contributor.institutionHarvard Univ
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Toronto
dc.date.accessioned2015-03-18T15:54:02Z
dc.date.available2015-03-18T15:54:02Z
dc.date.issued2014-01-01
dc.description.abstractDespite the remarkable improvements in breast cancer (BC) characterization, accurate prediction of BC clinical behavior is often still difficult to achieve. Some studies have investigated the association between the molecular subtype, namely the basal-like BC and the pattern of relapse, however only few investigated the association between relapse pattern and immunohistochemical defined triple-negative breast cancers (TNBCs). The aim of this study was to evaluate the pattern of relapse in patients with TNBC, namely the primary distant relapse site:One-hundred twenty nine (129) invasive breast carcinomas with follow-up information were classified according to the molecular subtype using immunohistochemistry for ER, PgR and Her2. The association between TNBC and distant relapse primary site was analyzed by logistic regression. Using multivariate logistic regression analysis patients with TNBC displayed only 0.09(95% CI: 0.00-0.74; p = 0.02) the odds of, the non-TNBC patients of developing bone primary relapse. Regarding visceral and lymph-node relapse, no differences between in this cohort were found.Though classically regarded as aggressive tumors, TNBCs rarely development primary relapse in bone when compared to non-TNBC, a clinical relevant fact when investigating a metastasis of an occult or non-sampled primary BC. (C) 2014 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniv Porto, IPATIMUP Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal
dc.description.affiliationHarvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
dc.description.affiliationUniv Fed Santa Catarina, Fac Med, Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Dept Pathol, Fac Med, Florianopolis, SC, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Dept Obstet & Gynaecol, Sch Med Sci, Campinas, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Dept Pathol, Fac Med Botucatu, Botucatu, SP, Brazil
dc.description.affiliationUniv Toronto, Dept Lab Med & Pathobiol, Fac Med, Univ Hlth Network, Toronto, ON M5G 2C4, Canada
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Pathol, Fac Med Botucatu, Botucatu, SP, Brazil
dc.description.sponsorshipFCT (Fundacao para a Ciencia e Tecnologia)
dc.description.sponsorshipIdFCT (Fundacao para a Ciencia e Tecnologia)HMSP-ICJ/0006/2012
dc.format.extent571-575
dc.identifierhttp://dx.doi.org/10.1016/j.prp.2014.05.011
dc.identifier.citationPathology Research And Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 210, n. 9, p. 571-575, 2014.
dc.identifier.doi10.1016/j.prp.2014.05.011
dc.identifier.issn0344-0338
dc.identifier.urihttp://hdl.handle.net/11449/116727
dc.identifier.wosWOS:000342247300006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPathology Research And Practice
dc.relation.ispartofjcr1.466
dc.relation.ispartofsjr0,547
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBreast canceren
dc.subjectTriple-negativeen
dc.subjectRecurrenceen
dc.subjectRelapseen
dc.subjectMetastasisen
dc.titlePrimary relapse site pattern in women with triple-negative breast canceren
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-3711-8681[6]
unesp.author.orcid0000-0003-1006-6946[6]
unesp.author.orcid0000-0002-4409-012X[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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