Expression of Ki-67 Antigen and Caspase-3 Protein in Benign Lesions and Esophageal Carcinoma

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dc.contributor.authorBellini, Marilanda Ferreira
dc.contributor.authorCury, Patricia Maluf
dc.contributor.authorSilva, Ana Elizabete [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.date.accessioned2014-05-20T14:01:00Z
dc.date.available2014-05-20T14:01:00Z
dc.date.issued2010-07-01
dc.description.abstractBackground: The present study aimed to evaluate apoptosis and cell proliferation alterations in esophageal benign lesions in comparison to esophageal carcinomas. Materials and Methods: Immunohistochemistry was performed for caspase-3 protein (CPP32) and Ki-67 antigen expression in the esophageal mucosa from patienis with Chagas disease (CD) with and without megaesophagus (CM), chronic esophagitis (CE), esophageal carcinoma (ESCC) and in normal mucosa (NM). Results: The Ki-67 labeling index (LI) was similar in all groups (range: 30%-48%), having no statistically significant difference among the groups. Positive CPP32 immunostaining was observed with similar frequency in the CD (30.8%), CM (30.4%) and CE (34.8%) groups, but it was increased in the ESCC group (55.5%); however, it was not statistically different from the other groups. No associations among the levels of CPP32 and Ki-67 expression were observed in the various groups, neither among parameters such as age, gender or alcohol and tobacco consumption. Conclusion: There were no evident changes in cell proliferation and apoptosis in benign lesions studied.en
dc.description.affiliationUNESP, Dept Biol, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationFAMERP Med Sch, Dept Pathol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Biol, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent2845-2849
dc.identifier.citationAnticancer Research. Athens: Int Inst Anticancer Research, v. 30, n. 7, p. 2845-2849, 2010.
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/11449/21551
dc.identifier.wosWOS:000280796400050
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofAnticancer Research
dc.relation.ispartofjcr1.865
dc.relation.ispartofsjr0,717
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectKi-67en
dc.subjectCPP32en
dc.subjectChagasic megaesophagusen
dc.subjectChronic esophagitisen
dc.subjectEsophageal squamous cell carcinomaen
dc.titleExpression of Ki-67 Antigen and Caspase-3 Protein in Benign Lesions and Esophageal Carcinomaen
dc.typeArtigo
dcterms.rightsHolderInt Inst Anticancer Research
unesp.author.lattes2503906319038306[3]
unesp.author.orcid0000-0003-1491-8878[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Biologia - IBILCE