Involvement of central alpha(1)- and mu(2)-adrenoceptors on cardiovascular responses to moxonidine

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dc.contributor.authorMoreira, Thiago S.
dc.contributor.authorTakakura, Ana C.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:49Z
dc.date.available2014-05-20T13:45:49Z
dc.date.issued2007-06-01
dc.description.abstractIn the present study we compared the effects produced by moxonidine (alpha(2)-adrenoceptor/imidazoline agonist) injected into the 4th cerebral ventricle and into the lateral cerebral ventricle on mean arterial pressure, heart rate and on renal, mesenteric and hindquarter vascular resistances, as well as the possible action of moxonidine on central alpha(1)- or alpha(2)-adrenoceptors to produce cardiovascular responses. Male Holtzman rats (n = 7-8) anesthetized with urethane (0.5 g/kg, intravenously - i.v.) and alpha-chloralose (60 mg/kg, i.v.) were used. Moxonidine (5, 10 and 20 nmol) injected into the 4th ventricle reduced arterial pressure (-19 +/- 5, -30 +/- 7 and -43 +/- 8 mmHg vs. vehicle: 2 +/- 4 mmHg), heart rate (-10 +/- 6, - 16 +/- 7 and -27 +/- 9 beats per minute - bpm, vs. vehicle: 4 +/- 5 bpm), and renal, mesenteric and hindquarter vascular resistances. Moxonidine (5, 10 and 20 nmol) into the lateral ventricle only reduced renal vascular resistance (-77 +/- 17%, - 85 +/- 13%, -89 +/- 10% vs. vehicle: 3 +/- 4%), without changes on arterial pressure, heart rate and mesenteric and hindquarter vascular resistances. Pre-treatment with the selective alpha(2)-adrenoceptor antagonist yohimbine (80, 160 and 320 nmol) injected into the 4th ventricle attenuated the hypotension (-32 +/- 5, -25 +/- 4 and -12 +/- 6 mmHg), bradycardia (-26 +/- 11, -23 +/- 5 and -11 +/- 6 bpm) and the reduction in renal, mesenteric and hindquarter vascular resistances produced by moxonidine (20 nmol) into the 4th ventricle. Pretreatment with yohimbine (320 nmol) into the lateral ventricle did not change the renal vasodilation produced by moxonidine (20 nmol) into the lateral ventricle. The alpha(1)-adrenoceptor antagonist prazosin (320 nmol) injected into the 4th ventricle did not affect the cardiovascular effects of moxonidine. However, prazosin (80, 160 and 320 nmol) into the lateral ventricle abolished the renal vasodilation (-17 +/- 4, -6 +/- 9 and 2 +/- 11%) produced by moxonidine. The results indicate that the decrease in renal vascular resistance due to moxonidine action in the forebrain is mediated by alpha(1)-adrenoceptors, while the cardiovascular effects produced by moxonidine acting in the brainstern depend at least partially on the activation of coadrenoceptors. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed São Paulo, Dept Physiol, Escola Paulista Med, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Physiol & Pathol, Fac Odontol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Physiol & Pathol, Fac Odontol, BR-14801903 Araraquara, SP, Brazil
dc.format.extent164-171
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2007.02.002
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 563, n. 1-3, p. 164-171, 2007.
dc.identifier.doi10.1016/j.ejphar.2007.02.002
dc.identifier.issn0014-2999
dc.identifier.lattes1023597870118105
dc.identifier.lattes4544450092427426
dc.identifier.urihttp://hdl.handle.net/11449/16158
dc.identifier.wosWOS:000246608300021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.ispartofjcr3.040
dc.relation.ispartofsjr1,057
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectarterial pressurept
dc.subjectvascular resistancept
dc.subjectalpha(1)- and alpha(2)-adrenoceptorspt
dc.subjecthypotensionpt
dc.subjectanti-hypertensivept
dc.subjectsympathetic activitypt
dc.titleInvolvement of central alpha(1)- and mu(2)-adrenoceptors on cardiovascular responses to moxonidineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1023597870118105
unesp.author.lattes4544450092427426[4]
unesp.author.orcid0000-0002-1395-4036[4]
unesp.author.orcid0000-0003-1167-4441[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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