Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationship

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dc.contributor.authorRibeiro, Daniel Araki
dc.contributor.authorKitakawa, Darcio
dc.contributor.authorDomingues, Maria Aparecida Custódio [UNESP]
dc.contributor.authorGuimaraes Cabral, Luiz Antonio
dc.contributor.authorMarques, Mariângela Esther Alencar [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:02Z
dc.date.available2014-05-20T13:37:02Z
dc.date.issued2007-08-01
dc.description.abstractThis study was undertaken to investigate, by immunohistochermistry, the expression of survivin and inducible nitric oxide synthase during 4NQO-induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Ten animals were used as negative control. Although no histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, survivin and iNOS were expresssed (P < 0.05) in some cells of the 'normal' oral epithelium. In pre-neoplastic lesions at 12 weeks following carcinogen exposure, the levels of survivin and iNOS were increased (p < 0.05) when compared to negative control, being the strongest effect observed to iNOS. In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, survivin and iNOS were expressed in some tumor cells. Lack of immunoreactivity for both markers was observed in the negative control group. Taken together, our results support the belief that expression of survivin and iNOS are early events during malignant transformation and conversion of the oral mucosa. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed São Paulo, Dept Hlth Sci, São Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Sao Jose Campos Sch Dent, Dept Oral Diagnosis, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sao Jose Campos Sch Dent, Dept Oral Diagnosis, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Med Sch, Dept Pathol, São Paulo, Brazil
dc.format.extent131-137
dc.identifierhttp://dx.doi.org/10.1016/j.yexmp.2007.02.006
dc.identifier.citationExperimental and Molecular Pathology. San Diego: Academic Press Inc. Elsevier B.V., v. 83, n. 1, p. 131-137, 2007.
dc.identifier.doi10.1016/j.yexmp.2007.02.006
dc.identifier.issn0014-4800
dc.identifier.lattes5051118752980903
dc.identifier.lattes0585723113037140
dc.identifier.lattes7528116925519142
dc.identifier.urihttp://hdl.handle.net/11449/12775
dc.identifier.wosWOS:000247716800020
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofExperimental and Molecular Pathology
dc.relation.ispartofjcr2.566
dc.relation.ispartofsjr1,023
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsurvivinpt
dc.subjectnitric oxidept
dc.subjectrat tongue mucosapt
dc.subjectoral squamous cell carcinomapt
dc.subject4-nitroquinoline 1-oxidept
dc.subjectmalignant transformationpt
dc.titleSurvivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationshipen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5051118752980903
unesp.author.lattes0585723113037140
unesp.author.lattes7528116925519142
unesp.author.orcid0000-0001-6947-5627[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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