Corticosterone does not change open elevated plus maze-induced antinociception in mice

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dc.contributor.authorMendes-Gomes, Joyce [UNESP]
dc.contributor.authorMiguel, Tarciso Tadeu [UNESP]
dc.contributor.authorSantana Amaral, Vanessa Cristiane [UNESP]
dc.contributor.authorNunes-de-Souza, Ricardo Luiz [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUnidade Univ Ciencias Exatas & Tecnol
dc.date.accessioned2014-05-20T15:34:36Z
dc.date.available2014-05-20T15:34:36Z
dc.date.issued2011-09-01
dc.description.abstractIt has been demonstrated that the exposure of rodents to the standard elevated plus-maze (sEPM: 2 open and 2 enclosed arms) elicits defensive behavioral reactions and antinociception and also activates the hypothalamo-pituitary-adrenal (HPA) axis. We have recently reported that EPM-induced antinociception is particularly observed when rats and mice are exposed to a totally open EPM (oEPM: 4 open arms). Given that the oEPM seems to be a more aversive situation than the sEPM, we hypothesized that oEPM exposure would induce higher plasma levels of corticosterone than sEPM exposure in mice. In this study, we investigated the influence of exposure to eEPM (enclosed EPM: 4 enclosed arms), sEPM or oEPM on plasma corticosterone levels in mice, with or without prior nociceptive stimulation (2.5% formalin injection into the right hind paw). We also tested whether the nociceptive response in the formalin test and oEPM-induced antinociception are altered by adrenalectomy. Results showed that oEPM-exposed mice spent less time licking the injected paw than sEPM- and eEPM-exposed animals. All three types of EPM exposure increased plasma corticosterone when compared to the basal group, but sEPM- and oEPM-exposed mice showed higher corticosterone levels than eEPM-exposed mice. Prior nociceptive stimulation (formalin injection) did not enhance the plasma corticosterone response induced by the three types of EPM exposure. Indeed, formalin injection appeared to provoke a ceiling effect on plasma corticosterone concentration. Furthermore, neither the nociceptive response in the formalin test nor oEPM-induced antinociception was changed by adrenalectomy. Present results suggest that oEPM antinociception does not depend on corticosterone release in mice. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationFFCLRP USP Av, Programa Posgrad Psicobiol, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationFac Ciencias Farmaceut UNESP Rod, Lab Neuropsicofarmacol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUFSCAR UNESP Rod, Programa Interinst Posgrad Ciencias Fisiol, BR-13565 São Carlos, SP, Brazil
dc.description.affiliationUnidade Univ Ciencias Exatas & Tecnol, BR-75132903 Anapolis, GO, Brazil
dc.description.affiliationUnespFac Ciencias Farmaceut UNESP Rod, Lab Neuropsicofarmacol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUFSCAR UNESP Rod, Programa Interinst Posgrad Ciencias Fisiol, BR-13565 São Carlos, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.description.sponsorshipIdFAPESP: 05/01988-3
dc.description.sponsorshipIdFAPESP: 05/05171-1
dc.description.sponsorshipIdCNPq: 142266/2008-6
dc.description.sponsorshipIdCNPq: 303580/2009-7
dc.format.extent408-413
dc.identifierhttp://dx.doi.org/10.1016/j.yhbeh.2011.07.004
dc.identifier.citationHormones and Behavior. San Diego: Academic Press Inc. Elsevier B.V., v. 60, n. 4, p. 408-413, 2011.
dc.identifier.doi10.1016/j.yhbeh.2011.07.004
dc.identifier.fileWOS000294834100012.pdf
dc.identifier.issn0018-506X
dc.identifier.urihttp://hdl.handle.net/11449/42601
dc.identifier.wosWOS:000294834100012
dc.language.isoeng
dc.publisherAcademic Press Inc. Elsevier B.V.
dc.relation.ispartofHormones and Behavior
dc.relation.ispartofjcr4.418
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAnxietyen
dc.subjectFearen
dc.subjectDifferent types of EPMen
dc.subjectAntinociceptionen
dc.subjectFormalin testen
dc.subjectCorticosteroneen
dc.subjectAdrenalectomyen
dc.subjectMiceen
dc.titleCorticosterone does not change open elevated plus maze-induced antinociception in miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc. Elsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR