Protective Effect of HLA-DRB1*11 and Predisposition of HLA-C*04 in the Development of Severe Liver Damage in Brazilian Patients with Chronic Hepatitis C Virus Infection

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dc.contributor.authorMarangon, A. V.
dc.contributor.authorSilva, Giovanni Faria [UNESP]
dc.contributor.authorde Moraes, C. F. V. [UNESP]
dc.contributor.authorGrotto, Rejane Maria Tommasini [UNESP]
dc.contributor.authorPardini, Maria Ines de Moura Campos [UNESP]
dc.contributor.authorde Pauli, D. S.
dc.contributor.authorVisentainer, J. E. L.
dc.contributor.authorSell, A. M.
dc.contributor.authorMoliterno, R. A.
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-20T15:31:54Z
dc.date.available2014-05-20T15:31:54Z
dc.date.issued2012-10-01
dc.description.abstractThe objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty-five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A*, B*, C*) and class II (DRB1*, DQA1*, DQB1*) typing were carried out by PCR-SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1*11 (5.0% versus 18.2%, P = 0.0016, OR = 0.23, CI 95% = 0.090.58; Pc=0.0208) and DRB1*11-DQA1*05-DQB1*03 haplotype (4.2% versus 15.3%, P = 0.0032; OR = 0.24, CI 95% = 0.08-0.64). Liver damage was associated with HLA-C*04 in patients with <20 years of infection (38.4% versus 9.1%, P = 0.002, OR = 6.25, CI 95% = 1.9719.7; Pc=0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type-1 chronically infected Brazilian patients.en
dc.description.affiliationUniversidade Estadual de Maringá (UEM), Lab Imunogenet, Dept Ciencias Basicas Saude, UEM, BR-87020900 Maringa, Parana, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Div Gastroenterol, Dept Internal Med,Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Mol Biol Lab, Blood Transfus Ctr,Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Estadual de Londrina (UEL), UEL, Clin Hosp Londrina, Londrina, PR, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Div Gastroenterol, Dept Internal Med,Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Mol Biol Lab, Blood Transfus Ctr,Botucatu Med Sch, Botucatu, SP, Brazil
dc.format.extent440-447
dc.identifierhttp://dx.doi.org/10.1111/j.1365-3083.2012.02755.x
dc.identifier.citationScandinavian Journal of Immunology. Hoboken: Wiley-blackwell, v. 76, n. 4, p. 440-447, 2012.
dc.identifier.doi10.1111/j.1365-3083.2012.02755.x
dc.identifier.issn0300-9475
dc.identifier.lattes6322604200510676
dc.identifier.lattes4619588334582084
dc.identifier.lattes7788448564326585
dc.identifier.orcid0000-0002-4035-9486
dc.identifier.orcid0000-0002-4035-9486
dc.identifier.urihttp://hdl.handle.net/11449/40923
dc.identifier.wosWOS:000308711700012
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofScandinavian Journal of Immunology
dc.relation.ispartofjcr2.314
dc.relation.ispartofsjr0,891
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleProtective Effect of HLA-DRB1*11 and Predisposition of HLA-C*04 in the Development of Severe Liver Damage in Brazilian Patients with Chronic Hepatitis C Virus Infectionen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes6322604200510676
unesp.author.lattes4619588334582084
unesp.author.lattes7788448564326585[4]
unesp.author.orcid0000-0002-5815-7903[7]
unesp.author.orcid0000-0002-4035-9486[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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